RESUMO
The effects of maternal use of methadone during pregnancy on tests of thyroid function were studied in 14 women and their offspring. Twelve normal nonaddicted women and their infants served as a control group. Concentrations of thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3) were not significantly different in maternal and cord serum, and in infant serum at age 24 hours. There was no significant difference in infants' TSH concentrations at 2, 3, and 7 days of age. At 2 and 7 days, T3 levels were significantly higher in the methadone than in the control group (P = .01 and less than .01, respectively). At 3 days, differences were of borderline significance (P = .08). Increased T4 levels in the methadone group of infants were statistically significant at 2 days (P less than .01) and at 3 and 7 days (P = .05). The mechanisms responsible for the biochemical evidence of hyperthyroidism were not determined, but may have been related to altered autonomic function and/or increased metabolic activity which occurs during neonatal narcotic withdrawal.
Assuntos
Sangue Fetal/metabolismo , Metadona/farmacologia , Glândula Tireoide/efeitos dos fármacos , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangue , Adolescente , Adulto , Fatores Etários , Feminino , Humanos , Recém-Nascido , Doenças do Recém-Nascido/metabolismo , Masculino , Troca Materno-Fetal , Gravidez , Síndrome de Abstinência a Substâncias/metabolismo , Glândula Tireoide/fisiologiaRESUMO
The characteristics of eight mothers of ten infants born with typical features of the fetal alcohol syndrome (FAS) are presented. These chronic alcoholic mothers have poor obstetric histories, tend to have poor or no prenatal care and may repeat pregnancies which result in infants with FAS. Family planning counseling appears unhelpful.
Assuntos
Transtornos do Espectro Alcoólico Fetal/complicações , Comportamento Materno , Maus-Tratos Infantis , Criança Abandonada , Face , Feminino , Transtornos do Crescimento/etiologia , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Gravidez , Síndrome de Abstinência a Substâncias/complicaçõesRESUMO
An infant with congenital chondrodysplasia punctata with a secondary deformation of umbilical cord hernia is reported. The paper discusses deformation syndromes as anomalies due to unusual mechanical or intrinsic factors.
Assuntos
Condrodisplasia Punctata/complicações , Genes Recessivos , Hérnia Umbilical/complicações , Condrodisplasia Punctata/diagnóstico por imagem , Condrodisplasia Punctata/genética , Humanos , Recém-Nascido , Masculino , RadiografiaRESUMO
Six infants with dysmorphic features of the fetal alcohol syndrome presented with symptoms of withdrawal from alcohol similar to those observed in adults and animals. Symptoms were characterized by irritability, tremors, spontaneous seizures, opisthotonos, and abdominal distention. A comparison of symptoms is made to animal and withdrawal from ethanol and to the neonatal narcotic withdrawal syndrome.
Assuntos
Etanol , Doenças do Recém-Nascido , Síndrome de Abstinência a Substâncias , Sintomas Afetivos/etiologia , Alcoolismo/complicações , Animais , Face , Feminino , Doenças Fetais/etiologia , Gastroenteropatias/etiologia , Humanos , Recém-Nascido , Troca Materno-Fetal , Camundongos , Tono Muscular , Gravidez , Complicações na Gravidez , Tremor/etiologiaRESUMO
Skin sloughs and necrosis from hypertonic solutions may occur in premature infants receiving peripheral intravenous fluid therapy. A simple multiple puncture method is proposed to remove the infiltrate and prevent skin sloughs.