Detalhe da pesquisa
1.
The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins.
FASEB J
; 34(2): 2198-2212, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31907988
2.
Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.
J Pharmacol Exp Ther
; 370(1): 44-53, 2019 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31004077
3.
Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine.
Mol Pharmacol
; 92(1): 48-56, 2017 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28408657
4.
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.
J Pharmacol Exp Ther
; 359(1): 91-101, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27440420
5.
3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease.
Pharmacol Res
; 100: 64-72, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26238175
6.
Evaluation of in situ generated valproyl 1-O-ß-acyl glucuronide in valproic acid toxicity in sandwich-cultured rat hepatocytes.
Drug Metab Dispos
; 42(11): 1834-42, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25147275
7.
Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system.
Toxicol Appl Pharmacol
; 277(2): 221-30, 2014 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24721719
8.
Selective agonism of human pregnane X receptor by individual ginkgolides.
Drug Metab Dispos
; 40(6): 1113-21, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22393123
9.
Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
Drug Metab Dispos
; 40(1): 178-86, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22019630
10.
Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
Toxicol Appl Pharmacol
; 264(3): 413-22, 2012 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22940460
11.
Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.
J Pharmacol Exp Ther
; 339(2): 704-15, 2011 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-21862659
12.
Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.
J Pharmacol Exp Ther
; 336(3): 816-26, 2011 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21131266
13.
Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
Toxicol Appl Pharmacol
; 252(3): 318-24, 2011 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21397622
14.
Estradiol-mediated suppression of CYP1B1 expression in mouse MA-10 Leydig cells is independent of protein kinase A and estrogen receptor.
Mol Cell Biochem
; 358(1-2): 387-95, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21785971
15.
Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.
J Pharmacol Exp Ther
; 335(3): 771-80, 2010 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-20739453
16.
Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin.
J Pineal Res
; 48(1): 55-64, 2010 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-19919601
17.
Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols.
Drug Metab Dispos
; 37(9): 1931-7, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19487249
18.
Developmental expression and endocrine regulation of CYP1B1 in rat testis.
Drug Metab Dispos
; 37(3): 523-8, 2009 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-19074971
19.
Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.
Can J Physiol Pharmacol
; 87(9): 674-83, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19794518
20.
Identification of Ginkgo biloba as a novel activator of pregnane X receptor.
Drug Metab Dispos
; 36(11): 2270-6, 2008 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-18725505