Detalhe da pesquisa
1.
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature
; 603(7901): 439-444, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35296845
2.
Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing.
Bioorg Med Chem Lett
; 26(18): 4513-4517, 2016 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27503684
3.
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J Med Chem
; 67(5): 3935-3958, 2024 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38365209
4.
Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938.
Antimicrob Agents Chemother
; 56(7): 3767-75, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22526308
5.
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.
Bioorg Med Chem Lett
; 22(8): 2938-42, 2012 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22425564
6.
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
J Med Chem
; 65(7): 5675-5689, 2022 04 14.
Artigo
Inglês
| MEDLINE | ID: mdl-35332774
7.
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.
J Biol Chem
; 285(45): 34337-47, 2010 Nov 05.
Artigo
Inglês
| MEDLINE | ID: mdl-20801890
8.
Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of ß-D-2'-deoxy-2'-α-fluoro-2'-ß-C-methylguanosine.
Antimicrob Agents Chemother
; 55(6): 2566-75, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21444700
9.
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Bioorg Med Chem Lett
; 20(15): 4539-43, 2010 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20580554
10.
2'-deoxy-2'-α-fluoro-2'-ß-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
Bioorg Med Chem Lett
; 20(24): 7376-80, 2010 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21050754
11.
Rapid and sensitive detection of cardiac troponin I using a force enhanced immunoassay with nanoporous membrane.
Nanoscale
; 12(23): 12568-12577, 2020 Jun 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32500903
12.
An orally available non-nucleotide STING agonist with antitumor activity.
Science
; 369(6506)2020 08 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32820094
13.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 27(1): 32-40.e3, 2020 01 16.
Artigo
Inglês
| MEDLINE | ID: mdl-31653597
14.
Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
J Med Chem
; 51(4): 1035-42, 2008 Feb 28.
Artigo
Inglês
| MEDLINE | ID: mdl-18232653
15.
Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells.
Nitric Oxide
; 19(2): 184-91, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18472018
16.
Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.
J Med Chem
; 50(10): 2516-9, 2007 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-17439113
17.
Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines.
J Med Chem
; 49(26): 7836-42, 2006 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-17181166
18.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 28(2): 243, 2021 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33607006
19.
Regioselectivity of rhodium nitrene insertion. Syntheses of protected glycals of l-daunosamine, d-saccharosamine, and l-ristosamine.
Org Lett
; 7(9): 1785-8, 2005 Apr 28.
Artigo
Inglês
| MEDLINE | ID: mdl-15844906
20.
A synthesis of L-vancosamine derivatives from non-carbohydrate precursors by a short sequence based on the Marshall, McDonald, and Du Bois reactions.
Org Lett
; 5(21): 3891-3, 2003 Oct 16.
Artigo
Inglês
| MEDLINE | ID: mdl-14535736