Detalhe da pesquisa
1.
Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair.
Proc Natl Acad Sci U S A
; 121(16): e2400077121, 2024 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38598345
2.
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature
; 586(7827): 113-119, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32707573
3.
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Proc Natl Acad Sci U S A
; 120(20): e2300763120, 2023 05 16.
Artigo
Inglês
| MEDLINE | ID: mdl-37155889
4.
Pharmacological YAP activation promotes regenerative repair of cutaneous wounds.
Proc Natl Acad Sci U S A
; 120(28): e2305085120, 2023 07 11.
Artigo
Inglês
| MEDLINE | ID: mdl-37399395
5.
Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
Nat Chem Biol
; 19(3): 275-283, 2023 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36175661
6.
Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease.
Proc Natl Acad Sci U S A
; 119(40): e2210779119, 2022 10 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36161945
7.
Synthesis and structure-activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents.
Bioorg Med Chem Lett
; 98: 129596, 2024 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38142914
8.
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.
Nature
; 562(7728): 600-604, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30323285
9.
YAP-dependent proliferation by a small molecule targeting annexin A2.
Nat Chem Biol
; 17(7): 767-775, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33723431
10.
Multistep Synthesis of Analogues of Remdesivir: Incorporating Heterocycles at the C-1' Position.
J Org Chem
; 88(13): 9105-9122, 2023 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37276453
11.
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Med Chem Lett
; 89: 129306, 2023 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37116763
12.
Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition.
Bioorg Med Chem Lett
; 90: 129328, 2023 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37196868
13.
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.
J Am Chem Soc
; 143(33): 13044-13055, 2021 08 25.
Artigo
Inglês
| MEDLINE | ID: mdl-34387474
14.
Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Chem
; 108: 104614, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33508678
15.
Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors.
Proc Natl Acad Sci U S A
; 115(26): 6834-6839, 2018 06 26.
Artigo
Inglês
| MEDLINE | ID: mdl-29735709
16.
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.
Proc Natl Acad Sci U S A
; 115(42): 10750-10755, 2018 10 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30282735
17.
Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.
Proc Natl Acad Sci U S A
; 115(29): E6920-E6926, 2018 07 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29967151
18.
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.
J Am Chem Soc
; 142(19): 8972-8979, 2020 05 13.
Artigo
Inglês
| MEDLINE | ID: mdl-32302104
19.
Small molecule selectively suppresses MYC transcription in cancer cells.
Proc Natl Acad Sci U S A
; 114(13): 3497-3502, 2017 03 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28292893
20.
Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.
Proc Natl Acad Sci U S A
; 114(18): 4679-4684, 2017 05 02.
Artigo
Inglês
| MEDLINE | ID: mdl-28416697