Pesquisa | Secretaria de Estado da Saúde

1.

Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer.

Lin, Jia-Ren; Wang, Shu; Coy, Shannon; Chen, Yu-An; Yapp, Clarence; Tyler, Madison; Nariya, Maulik K; Heiser, Cody N; Lau, Ken S; Santagata, Sandro; Sorger, Peter K.

Cell ; 186(2): 363-381.e19, 2023 01 19.

Artigo Inglês | MEDLINE | ID: mdl-36669472

2.

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast.

Qin, Ning; Li, Lingyun; Ji, Xu; Pereira, Rui; Chen, Yu; Yin, Shile; Li, Chaokun; Wan, Xiaozhen; Qiu, Danye; Jiang, Junfeng; Luo, Hao; Zhang, Yueping; Dong, Genlai; Zhang, Yiming; Shi, Shuobo; Jessen, Henning J; Xia, Jianye; Chen, Yun; Larsson, Christer; Tan, Tianwei; Liu, Zihe; Nielsen, Jens.

Cell ; 186(4): 748-763.e15, 2023 02 16.

Artigo Inglês | MEDLINE | ID: mdl-36758548

3.

WeiTsing, a pericycle-expressed ion channel, safeguards the stele to confer clubroot resistance.

Wang, Wei; Qin, Li; Zhang, Wenjing; Tang, Linghui; Zhang, Chao; Dong, Xiaojing; Miao, Pei; Shen, Meng; Du, Huilong; Cheng, Hangyuan; Wang, Ke; Zhang, Xiangyun; Su, Min; Lu, Hongwei; Li, Chang; Gao, Qiang; Zhang, Xiaojuan; Huang, Yun; Liang, Chengzhi; Zhou, Jian-Min; Chen, Yu-Hang.

Cell ; 186(12): 2656-2671.e18, 2023 06 08.

Artigo Inglês | MEDLINE | ID: mdl-37295403

4.

A zinc chaperone mediates the flow of an inorganic commodity to an important cellular client.

Chen, Yu-Ying; O'Halloran, Thomas V.

Cell ; 185(12): 2013-2015, 2022 06 09.

Artigo Inglês | MEDLINE | ID: mdl-35688131

5.

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.

Luoma, Adrienne M; Suo, Shengbao; Wang, Yifan; Gunasti, Lauren; Porter, Caroline B M; Nabilsi, Nancy; Tadros, Jenny; Ferretti, Andrew P; Liao, Sida; Gurer, Cagan; Chen, Yu-Hui; Criscitiello, Shana; Ricker, Cora A; Dionne, Danielle; Rozenblatt-Rosen, Orit; Uppaluri, Ravindra; Haddad, Robert I; Ashenberg, Orr; Regev, Aviv; Van Allen, Eliezer M; MacBeath, Gavin; Schoenfeld, Jonathan D; Wucherpfennig, Kai W.

Cell ; 185(16): 2918-2935.e29, 2022 08 04.

Artigo Inglês | MEDLINE | ID: mdl-35803260

6.

The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling.

Bi, Guozhi; Su, Min; Li, Nan; Liang, Yu; Dang, Song; Xu, Jiachao; Hu, Meijuan; Wang, Jizong; Zou, Minxia; Deng, Yanan; Li, Qiyu; Huang, Shijia; Li, Jiejie; Chai, Jijie; He, Kangmin; Chen, Yu-Hang; Zhou, Jian-Min.

Cell ; 184(13): 3528-3541.e12, 2021 06 24.

Artigo Inglês | MEDLINE | ID: mdl-33984278

7.

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.

Yan, Liming; Ge, Ji; Zheng, Litao; Zhang, Ying; Gao, Yan; Wang, Tao; Huang, Yucen; Yang, Yunxiang; Gao, Shan; Li, Mingyu; Liu, Zhenyu; Wang, Haofeng; Li, Yingjian; Chen, Yu; Guddat, Luke W; Wang, Quan; Rao, Zihe; Lou, Zhiyong.

Cell ; 184(1): 184-193.e10, 2021 01 07.

Artigo Inglês | MEDLINE | ID: mdl-33232691

8.

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.

Rodda, Lauren B; Netland, Jason; Shehata, Laila; Pruner, Kurt B; Morawski, Peter A; Thouvenel, Christopher D; Takehara, Kennidy K; Eggenberger, Julie; Hemann, Emily A; Waterman, Hayley R; Fahning, Mitchell L; Chen, Yu; Hale, Malika; Rathe, Jennifer; Stokes, Caleb; Wrenn, Samuel; Fiala, Brooke; Carter, Lauren; Hamerman, Jessica A; King, Neil P; Gale, Michael; Campbell, Daniel J; Rawlings, David J; Pepper, Marion.

Cell ; 184(1): 169-183.e17, 2021 01 07.

Artigo Inglês | MEDLINE | ID: mdl-33296701

9.

Rebalancing TGFß1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy.

Saadey, Abbey A; Yousif, Amir; Osborne, Nicole; Shahinfar, Roya; Chen, Yu-Lin; Laster, Brooke; Rajeev, Meera; Bauman, Parker; Webb, Amy; Ghoneim, Hazem E.

Nat Immunol ; 24(2): 280-294, 2023 02.

Artigo Inglês | MEDLINE | ID: mdl-36543960

10.

CD4⁺ T cell calibration of antigen-presenting cells optimizes antiviral CD8⁺ T cell immunity.

Gressier, Elise; Schulte-Schrepping, Jonas; Petrov, Lev; Brumhard, Sophia; Stubbemann, Paula; Hiller, Anna; Obermayer, Benedikt; Spitzer, Jasper; Kostevc, Tomislav; Whitney, Paul G; Bachem, Annabell; Odainic, Alexandru; van de Sandt, Carolien; Nguyen, Thi H O; Ashhurst, Thomas; Wilson, Kayla; Oates, Clare V L; Gearing, Linden J; Meischel, Tina; Hochheiser, Katharina; Greyer, Marie; Clarke, Michele; Kreutzenbeck, Maike; Gabriel, Sarah S; Kastenmüller, Wolfgang; Kurts, Christian; Londrigan, Sarah L; Kallies, Axel; Kedzierska, Katherine; Hertzog, Paul J; Latz, Eicke; Chen, Yu-Chen E; Radford, Kristen J; Chopin, Michael; Schroeder, Jan; Kurth, Florian; Gebhardt, Thomas; Sander, Leif E; Sawitzki, Birgit; Schultze, Joachim L; Schmidt, Susanne V; Bedoui, Sammy.

Nat Immunol ; 24(6): 979-990, 2023 06.

Artigo Inglês | MEDLINE | ID: mdl-37188942

11.

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression.

Chen, Yi-Ju; Roumeliotis, Theodoros I; Chang, Ya-Hsuan; Chen, Ching-Tai; Han, Chia-Li; Lin, Miao-Hsia; Chen, Huei-Wen; Chang, Gee-Chen; Chang, Yih-Leong; Wu, Chen-Tu; Lin, Mong-Wei; Hsieh, Min-Shu; Wang, Yu-Tai; Chen, Yet-Ran; Jonassen, Inge; Ghavidel, Fatemeh Zamanzad; Lin, Ze-Shiang; Lin, Kuen-Tyng; Chen, Ching-Wen; Sheu, Pei-Yuan; Hung, Chen-Ting; Huang, Ke-Chieh; Yang, Hao-Chin; Lin, Pei-Yi; Yen, Ta-Chi; Lin, Yi-Wei; Wang, Jen-Hung; Raghav, Lovely; Lin, Chien-Yu; Chen, Yan-Si; Wu, Pei-Shan; Lai, Chi-Ting; Weng, Shao-Hsing; Su, Kang-Yi; Chang, Wei-Hung; Tsai, Pang-Yan; Robles, Ana I; Rodriguez, Henry; Hsiao, Yi-Jing; Chang, Wen-Hsin; Sung, Ting-Yi; Chen, Jin-Shing; Yu, Sung-Liang; Choudhary, Jyoti S; Chen, Hsuan-Yu; Yang, Pan-Chyr; Chen, Yu-Ju.

Cell ; 182(1): 226-244.e17, 2020 07 09.

Artigo Inglês | MEDLINE | ID: mdl-32649875

12.

SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X.

Wang, Chen-Yu; Jégu, Teddy; Chu, Hsueh-Ping; Oh, Hyun Jung; Lee, Jeannie T.

Cell ; 174(2): 406-421.e25, 2018 07 12.

Artigo Inglês | MEDLINE | ID: mdl-29887375

13.

DDX21 mediates co-transcriptional RNA m⁶A modification to promote transcription termination and genome stability.

Hao, Jin-Dong; Liu, Qian-Lan; Liu, Meng-Xia; Yang, Xing; Wang, Liu-Ming; Su, Si-Yi; Xiao, Wen; Zhang, Meng-Qi; Zhang, Yi-Chang; Zhang, Lan; Chen, Yu-Sheng; Yang, Yun-Gui; Ren, Jie.

Mol Cell ; 84(9): 1711-1726.e11, 2024 May 02.

Artigo Inglês | MEDLINE | ID: mdl-38569554

14.

Minor intron splicing is critical for survival of lethal prostate cancer.

Augspach, Anke; Drake, Kyle D; Roma, Luca; Qian, Ellen; Lee, Se Ri; Clarke, Declan; Kumar, Sushant; Jaquet, Muriel; Gallon, John; Bolis, Marco; Triscott, Joanna; Galván, José A; Chen, Yu; Thalmann, George N; Kruithof-de Julio, Marianna; Theurillat, Jean-Philippe P; Wuchty, Stefan; Gerstein, Mark; Piscuoglio, Salvatore; Kanadia, Rahul N; Rubin, Mark A.

Mol Cell ; 83(12): 1983-2002.e11, 2023 Jun 15.

Artigo Inglês | MEDLINE | ID: mdl-37295433

15.

Integrative clinical genomics of advanced prostate cancer.

Robinson, Dan; Van Allen, Eliezer M; Wu, Yi-Mi; Schultz, Nikolaus; Lonigro, Robert J; Mosquera, Juan-Miguel; Montgomery, Bruce; Taplin, Mary-Ellen; Pritchard, Colin C; Attard, Gerhardt; Beltran, Himisha; Abida, Wassim; Bradley, Robert K; Vinson, Jake; Cao, Xuhong; Vats, Pankaj; Kunju, Lakshmi P; Hussain, Maha; Feng, Felix Y; Tomlins, Scott A; Cooney, Kathleen A; Smith, David C; Brennan, Christine; Siddiqui, Javed; Mehra, Rohit; Chen, Yu; Rathkopf, Dana E; Morris, Michael J; Solomon, Stephen B; Durack, Jeremy C; Reuter, Victor E; Gopalan, Anuradha; Gao, Jianjiong; Loda, Massimo; Lis, Rosina T; Bowden, Michaela; Balk, Stephen P; Gaviola, Glenn; Sougnez, Carrie; Gupta, Manaswi; Yu, Evan Y; Mostaghel, Elahe A; Cheng, Heather H; Mulcahy, Hyojeong; True, Lawrence D; Plymate, Stephen R; Dvinge, Heidi; Ferraldeschi, Roberta; Flohr, Penny; Miranda, Susana.

Cell ; 161(5): 1215-1228, 2015 May 21.

Artigo Inglês | MEDLINE | ID: mdl-26000489

16.

Observation and quantification of the pseudogap in unitary Fermi gases.

Li, Xi; Wang, Shuai; Luo, Xiang; Zhou, Yu-Yang; Xie, Ke; Shen, Hong-Chi; Nie, Yu-Zhao; Chen, Qijin; Hu, Hui; Chen, Yu-Ao; Yao, Xing-Can; Pan, Jian-Wei.

Nature ; 626(7998): 288-293, 2024 Feb.

Artigo Inglês | MEDLINE | ID: mdl-38326594

17.

Sex differences orchestrated by androgens at single-cell resolution.

Nature ; 629(8010): 193-200, 2024 May.

Artigo Inglês | MEDLINE | ID: mdl-38600383

18.

A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase.

Bauer, Benedikt W; Shemesh, Tom; Chen, Yu; Rapoport, Tom A.

Cell ; 157(6): 1416-1429, 2014 Jun 05.

Artigo Inglês | MEDLINE | ID: mdl-24906156

19.

Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Karthaus, Wouter R; Iaquinta, Phillip J; Drost, Jarno; Gracanin, Ana; van Boxtel, Ruben; Wongvipat, John; Dowling, Catherine M; Gao, Dong; Begthel, Harry; Sachs, Norman; Vries, Robert G J; Cuppen, Edwin; Chen, Yu; Sawyers, Charles L; Clevers, Hans C.

Cell ; 159(1): 163-175, 2014 Sep 25.

Artigo Inglês | MEDLINE | ID: mdl-25201529

20.

Organoid cultures derived from patients with advanced prostate cancer.

Gao, Dong; Vela, Ian; Sboner, Andrea; Iaquinta, Phillip J; Karthaus, Wouter R; Gopalan, Anuradha; Dowling, Catherine; Wanjala, Jackline N; Undvall, Eva A; Arora, Vivek K; Wongvipat, John; Kossai, Myriam; Ramazanoglu, Sinan; Barboza, Luendreo P; Di, Wei; Cao, Zhen; Zhang, Qi Fan; Sirota, Inna; Ran, Leili; MacDonald, Theresa Y; Beltran, Himisha; Mosquera, Juan-Miguel; Touijer, Karim A; Scardino, Peter T; Laudone, Vincent P; Curtis, Kristen R; Rathkopf, Dana E; Morris, Michael J; Danila, Daniel C; Slovin, Susan F; Solomon, Stephen B; Eastham, James A; Chi, Ping; Carver, Brett; Rubin, Mark A; Scher, Howard I; Clevers, Hans; Sawyers, Charles L; Chen, Yu.

Cell ; 159(1): 176-187, 2014 Sep 25.

Artigo Inglês | MEDLINE | ID: mdl-25201530

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