Malignancy diagnosis of liver lesion in contrast enhanced ultrasound using an end-to-end method based on deep learning.

BACKGROUND: Contrast-enhanced ultrasound (CEUS) is considered as an efficient tool for focal liver lesion characterization, given it allows real-time scanning and provides dynamic tissue perfusion information. An accurate diagnosis of liver lesions with CEUS requires a precise interpretation of CEUS images. However,it is a highly experience dependent task which requires amount of training and practice. To help improve the constrains, this study aims to develop an end-to-end method based on deep learning to make malignancy diagnosis of liver lesions using CEUS. METHODS: A total of 420 focal liver lesions with 136 benign cases and 284 malignant cases were included. A deep learning model based on a two-dimensional convolution neural network, a long short-term memory (LSTM), and a linear classifier (with sigmoid) was developed to analyze the CEUS loops from different contrast imaging phases. For comparison, a 3D-CNN based method and a machine-learning (ML)-based time-intensity curve (TIC) method were also implemented for performance evaluation. RESULTS: Results of the 4-fold validation demonstrate that the mean AUC is 0.91, 0.88, and 0.78 for the proposed method, the 3D-CNN based method, and the ML-based TIC method, respectively. CONCLUSIONS: The proposed CNN-LSTM method is promising in making malignancy diagnosis of liver lesions in CEUS without any additional manual features selection.

Ultrafast Ultrasound Imaging as an Inverse Problem: Matrix-Free Sparse Image Reconstruction.

Conventional ultrasound (US) image reconstruction methods rely on delay-and-sum (DAS) beamforming, which is a relatively poor solution to the image reconstruction problem. An alternative to DAS consists in using iterative techniques, which require both an accurate measurement model and a strong prior on the image under scrutiny. Toward this goal, much effort has been deployed in formulating models for US imaging, which usually require a large amount of memory to store the matrix coefficients. We present two different techniques, which take advantage of fast and matrix-free formulations derived for the measurement model and its adjoint, and rely on sparsity of US images in well-chosen models. Sparse regularization is used for enhanced image reconstruction. Compressed beamforming exploits the compressed sensing framework to restore high-quality images from fewer raw data than state-of-the-art approaches. Using simulated data and in vivo experimental acquisitions, we show that the proposed approach is three orders of magnitude faster than non-DAS state-of-the-art methods, with comparable or better image quality.

Reconstruction of Enhanced Ultrasound Images From Compressed Measurements Using Simultaneous Direction Method of Multipliers.

High-resolution ultrasound (US) image reconstruction from a reduced number of measurements is of great interest in US imaging, since it could enhance both frame rate and image resolution. Compressive deconvolution (CD), combining compressed sensing and image deconvolution, represents an interesting possibility to consider this challenging task. The model of CD includes, in addition to the compressive sampling matrix, a 2-D convolution operator carrying the information on the system point spread function. Through this model, the resolution of reconstructed US images from compressed measurements mainly depends on three aspects: the acquisition setup, i.e., the incoherence of the sampling matrix, the image regularization, i.e., the sparsity prior, and the optimization technique. In this paper, we mainly focused on the last two aspects. We proposed a novel simultaneous direction method of multipliers based optimization scheme to invert the linear model, including two regularization terms expressing the sparsity of the RF images in a given basis and the generalized Gaussian statistical assumption on tissue reflectivity functions. The performance of the method is evaluated on both simulated and in vivo data.

Compressive Deconvolution in Medical Ultrasound Imaging.

The interest of compressive sampling in ultrasound imaging has been recently extensively evaluated by several research teams. Following the different application setups, it has been shown that the RF data may be reconstructed from a small number of measurements and/or using a reduced number of ultrasound pulse emissions. Nevertheless, RF image spatial resolution, contrast and signal to noise ratio are affected by the limited bandwidth of the imaging transducer and the physical phenomenon related to US wave propagation. To overcome these limitations, several deconvolution-based image processing techniques have been proposed to enhance the ultrasound images. In this paper, we propose a novel framework, named compressive deconvolution, that reconstructs enhanced RF images from compressed measurements. Exploiting an unified formulation of the direct acquisition model, combining random projections and 2D convolution with a spatially invariant point spread function, the benefit of our approach is the joint data volume reduction and image quality improvement. The proposed optimization method, based on the Alternating Direction Method of Multipliers, is evaluated on both simulated and in vivo data.

A simulation study on the choice of regularization parameter in ℓ2-norm ultrasound image restoration.

Ultrasound image deconvolution has been widely investigated in the literature. Among the existing approaches, the most common are based on ℓ2-norm regularization (or Tikhonov optimization) or the well-known Wiener filtering. However, the success of the Wiener filter in practical situations largely depends on the choice of the regularization hyperparameter. An appropriate choice is necessary to guarantee the balance between data fidelity and smoothness of the deconvolution result. In this paper, we revisit different approaches for automatically choosing this regularization parameter and compare them in the context of ultrasound image deconvolution via Wiener filtering. Two synthetic ultrasound images are used in order to compare the performances of the addressed methods.