[Abnormal effect of nitrosation inhibitors in human gastric juice]. / Anomal'nyi éffekt ingibitorov nitrozirovaniia pri deistvii ikh v srede zheludochnogo soka liudei.

The paper discusses the effect of vitamins C and E and Plantaglucide on nitroso compounds yield in the course of nitrosation of amines in human gastric juice. The study group included 56 subjects. The above drugs capable of inhibiting in vitro nitrosation produced an anomalous effect in gastric juice of some subjects, i.e. potentiated nitroso compounds yield in nitrosation of amines by sodium nitrite. The said action of vitamins C and E was apparent in dimethylamine and amidopyrine nitrosation but it was not in morpholine nitrosation. Sharply increased levels in nitroso compounds were observed in some mice fed precursors of nitroso compounds in combination with vitamin C and Plantaglucide. These data point to an anomalous effect of the drugs on the body.

[Effect of human gastric juice on dimethylamine nitrosation by sodium nitrite]. / Vliianie zheludochnogo soka na nitrozirovanie dimetilamina nitritom natriia.

The study was concerned with evaluation of the effect of human gastric juice (samples obtained from 157 subjects) on in vitro dimethylnitrosamine nitrosation by sodium nitrite versus gastric mucosa pathology (gastritis, polyps, ulcer, cancer), gastric juice pH and nitrate ion level. Also, the influence of gastric juice glycosaminoglycans and glycoproteins levels as well as N-acetylneuraminic acid isolated from porcine blood was assessed. An increased nitrosating activity of gastric juice was observed in cases of gastritis and ulcer and in those with low nitrate ion activity. Glycosaminoglycans and glycoproteins were found to inhibit nitrosation. N-acetylneuraminic acid in the concentrations used exerted no effect on dimethylnitrosamine nitrosation by sodium nitrite.

[The dependence of the nitrosation activity of the gastric juice in humans on their age and the type of pathological status of the gastric mucosa]. / Zavisimost' nitroziruiushchei aktivnosti zheludochnogo soka liudei ot vozrasta i tipa patologicheskogo sostoianiia slizistoi obolochki zheludka.

The study involved two groups of patients aged 6-14 and 40-60 years, and identification of different conditions of gastric mucosa. The study has established a correlation between the nitrosation activity and acidity of gastric juice and the pathological condition of the gastric mucosa. Enhanced nitrosation activity was observed in samples with a pH under 4.0. That activity was at its lowest in cases of normal gastric mucosa, and at its peak--in high-acidity superficial and erosive gastritis. In cases of superficial gastritis with similar levels of acidity, the nitrosation activity of gastric juice for different amines in children was 2-4 times that in adults. The difference in nitrosation levels for different amines tended to diminish with the decrease in the basicity of the amine in question. A linear correlation was observed between the free-radical activity of gastric juice samples and nitrosation activity (correlation coefficient, k = 0.72).

[Endoscopic ambulatory electroexcision of gastric polyps]. / Endoskopicheskaia elektroekstsiziia polipov zheludka v ambulatornykh usloviiakh.

An analysis of observations of 68 patients has shown that in certain patients the endoscopic electroexcision of gastric polyps can be fulfilled under conditions of the outpatient clinic. The safety of the operation depends on the patient's state and the preliminary assessment of the following factors: the anatomic shape, polyp size and width of its base. Electroexcisions can not be performed endoscopically for polyps on a false pedicle (due to high risk of bleedings from the vessels of the submucous layer) and plaque-shaped polyps (due to the absence of possibility to put a diathermic loop).