RESUMO
Bone marrow stem cells (BMSCs) are a group cells that function as an underlying cell source for bone tissue regeneration. However, the molecular mechanisms of how BMSCs are induced into apoptosis remains unclear. In the present study, it was demonstrated that the molecular mechanisms of BMSCs were exerted via microRNA15a5p (miR15a5p) in femoral head necrosis (FHN). Briefly, miRNA15a5p expression was elevated in a rat model of FHN. Overexpression of miR15a5p promoted the apoptosis of BMSCs and reduced cell growth through the Wnt/ßcatenin/peroxisome proliferatoractivated receptor γ (PPARγ) signaling pathway. Downregulation of miR15a5p reduced the apoptosis of BMSCs and promoted cell growth through the Wnt/ßcatenin/PPARγ signaling pathway. The activation of Wnt attenuated the effects of miR15a5p on the apoptosis of BMSCs via the ßcatenin/PPARγ signaling pathway. In conclusion, the present results indicated that miRNA15a5p was involved in the regulation of the apoptosis of BMSCs through regulating the Wnt/ßcatenin/PPARγ signaling pathway, which may serve an important role in the regulation of FHN.