Detalhe da pesquisa
1.
Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate.
Mol Ther
; 25(1): 71-78, 2017 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28129130
2.
Pharmacokinetics of Intravenous Finafloxacin in Healthy Volunteers.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28784673
3.
Safety and efficacy of RNAi therapy for transthyretin amyloidosis.
N Engl J Med
; 369(9): 819-29, 2013 Aug 29.
Artigo
Inglês
| MEDLINE | ID: mdl-23984729
4.
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.
Lancet
; 383(9911): 60-68, 2014 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-24094767
5.
Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.
Br J Clin Pharmacol
; 79(3): 477-91, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25223836
6.
QT effect of semagacestat at therapeutic and supratherapeutic doses.
Int J Clin Pharmacol Ther
; 50(4): 290-9, 2012 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-22456300
7.
A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.
Alzheimers Dement (N Y)
; 1(3): 182-195, 2015 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-29854937