Pesquisa | Secretaria de Estado da Saúde

1.

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth.

Hu, Baoli; Wang, Qianghu; Wang, Y Alan; Hua, Sujun; Sauvé, Charles-Etienne Gabriel; Ong, Derrick; Lan, Zheng D; Chang, Qing; Ho, Yan Wing; Monasterio, Marta Moreno; Lu, Xin; Zhong, Yi; Zhang, Jianhua; Deng, Pingna; Tan, Zhi; Wang, Guocan; Liao, Wen-Ting; Corley, Lynda J; Yan, Haiyan; Zhang, Junxia; You, Yongping; Liu, Ning; Cai, Linbo; Finocchiaro, Gaetano; Phillips, Joanna J; Berger, Mitchel S; Spring, Denise J; Hu, Jian; Sulman, Erik P; Fuller, Gregory N; Chin, Lynda; Verhaak, Roeland G W; DePinho, Ronald A.

Cell ; 167(5): 1281-1295.e18, 2016 11 17.

Artigo Inglês | MEDLINE | ID: mdl-27863244

2.

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer.

Kapoor, Avnish; Yao, Wantong; Ying, Haoqiang; Hua, Sujun; Liewen, Alison; Wang, Qiuyun; Zhong, Yi; Wu, Chang-Jiun; Sadanandam, Anguraj; Hu, Baoli; Chang, Qing; Chu, Gerald C; Al-Khalil, Ramsey; Jiang, Shan; Xia, Hongai; Fletcher-Sananikone, Eliot; Lim, Carol; Horwitz, Gillian I; Viale, Andrea; Pettazzoni, Piergiorgio; Sanchez, Nora; Wang, Huamin; Protopopov, Alexei; Zhang, Jianhua; Heffernan, Timothy; Johnson, Randy L; Chin, Lynda; Wang, Y Alan; Draetta, Giulio; DePinho, Ronald A.

Cell ; 179(5): 1239, 2019 Nov 14.

Artigo Inglês | MEDLINE | ID: mdl-31730860

3.

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.

Kapoor, Avnish; Yao, Wantong; Ying, Haoqiang; Hua, Sujun; Liewen, Alison; Wang, Qiuyun; Zhong, Yi; Wu, Chang-Jiun; Sadanandam, Anguraj; Hu, Baoli; Chang, Qing; Chu, Gerald C; Al-Khalil, Ramsey; Jiang, Shan; Xia, Hongai; Fletcher-Sananikone, Eliot; Lim, Carol; Horwitz, Gillian I; Viale, Andrea; Pettazzoni, Piergiorgio; Sanchez, Nora; Wang, Huamin; Protopopov, Alexei; Zhang, Jianhua; Heffernan, Timothy; Johnson, Randy L; Chin, Lynda; Wang, Y Alan; Draetta, Giulio; DePinho, Ronald A.

Cell ; 158(1): 185-197, 2014 Jul 03.

Artigo Inglês | MEDLINE | ID: mdl-24954535

4.

Diverse mechanisms of somatic structural variations in human cancer genomes.

Yang, Lixing; Luquette, Lovelace J; Gehlenborg, Nils; Xi, Ruibin; Haseley, Psalm S; Hsieh, Chih-Heng; Zhang, Chengsheng; Ren, Xiaojia; Protopopov, Alexei; Chin, Lynda; Kucherlapati, Raju; Lee, Charles; Park, Peter J.

Cell ; 153(4): 919-29, 2013 May 09.

Artigo Inglês | MEDLINE | ID: mdl-23663786

5.

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

Hu, Jian; Hwang, Soyoon Sarah; Liesa, Marc; Gan, Boyi; Sahin, Ergun; Jaskelioff, Mariela; Ding, Zhihu; Ying, Haoqiang; Boutin, Adam T; Zhang, Hailei; Johnson, Shawn; Ivanova, Elena; Kost-Alimova, Maria; Protopopov, Alexei; Wang, Yaoqi Alan; Shirihai, Orian S; Chin, Lynda; DePinho, Ronald A.

Cell ; 148(4): 651-63, 2012 Feb 17.

Artigo Inglês | MEDLINE | ID: mdl-22341440

6.

Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.

Ding, Zhihu; Wu, Chang-Jiun; Jaskelioff, Mariela; Ivanova, Elena; Kost-Alimova, Maria; Protopopov, Alexei; Chu, Gerald C; Wang, Guocan; Lu, Xin; Labrot, Emma S; Hu, Jian; Wang, Wei; Xiao, Yonghong; Zhang, Hailei; Zhang, Jianhua; Zhang, Jingfang; Gan, Boyi; Perry, Samuel R; Jiang, Shan; Li, Liren; Horner, James W; Wang, Y Alan; Chin, Lynda; DePinho, Ronald A.

Cell ; 148(5): 896-907, 2012 Mar 02.

Artigo Inglês | MEDLINE | ID: mdl-22341455

7.

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Ying, Haoqiang; Kimmelman, Alec C; Lyssiotis, Costas A; Hua, Sujun; Chu, Gerald C; Fletcher-Sananikone, Eliot; Locasale, Jason W; Son, Jaekyoung; Zhang, Hailei; Coloff, Jonathan L; Yan, Haiyan; Wang, Wei; Chen, Shujuan; Viale, Andrea; Zheng, Hongwu; Paik, Ji-hye; Lim, Carol; Guimaraes, Alexander R; Martin, Eric S; Chang, Jeffery; Hezel, Aram F; Perry, Samuel R; Hu, Jian; Gan, Boyi; Xiao, Yonghong; Asara, John M; Weissleder, Ralph; Wang, Y Alan; Chin, Lynda; Cantley, Lewis C; DePinho, Ronald A.

Cell ; 149(3): 656-70, 2012 Apr 27.

Artigo Inglês | MEDLINE | ID: mdl-22541435

8.

A landscape of driver mutations in melanoma.

Hodis, Eran; Watson, Ian R; Kryukov, Gregory V; Arold, Stefan T; Imielinski, Marcin; Theurillat, Jean-Philippe; Nickerson, Elizabeth; Auclair, Daniel; Li, Liren; Place, Chelsea; Dicara, Daniel; Ramos, Alex H; Lawrence, Michael S; Cibulskis, Kristian; Sivachenko, Andrey; Voet, Douglas; Saksena, Gordon; Stransky, Nicolas; Onofrio, Robert C; Winckler, Wendy; Ardlie, Kristin; Wagle, Nikhil; Wargo, Jennifer; Chong, Kelly; Morton, Donald L; Stemke-Hale, Katherine; Chen, Guo; Noble, Michael; Meyerson, Matthew; Ladbury, John E; Davies, Michael A; Gershenwald, Jeffrey E; Wagner, Stephan N; Hoon, Dave S B; Schadendorf, Dirk; Lander, Eric S; Gabriel, Stacey B; Getz, Gad; Garraway, Levi A; Chin, Lynda.

Cell ; 150(2): 251-63, 2012 Jul 20.

Artigo Inglês | MEDLINE | ID: mdl-22817889

9.

Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.

Kouri, Fotini M; Hurley, Lisa A; Daniel, Weston L; Day, Emily S; Hua, Youjia; Hao, Liangliang; Peng, Chian-Yu; Merkel, Timothy J; Queisser, Markus A; Ritner, Carissa; Zhang, Hailei; James, C David; Sznajder, Jacob I; Chin, Lynda; Giljohann, David A; Kessler, John A; Peter, Marcus E; Mirkin, Chad A; Stegh, Alexander H.

Genes Dev ; 38(7-8): 355, 2024 Apr 01.

Artigo Inglês | MEDLINE | ID: mdl-38772726

10.

Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration.

Rabbani, Piul; Takeo, Makoto; Chou, WeiChin; Myung, Peggy; Bosenberg, Marcus; Chin, Lynda; Taketo, M Mark; Ito, Mayumi.

Cell ; 145(6): 941-955, 2011 Jun 10.

Artigo Inglês | MEDLINE | ID: mdl-21663796

11.

The brothers RAF.

Kwong, Lawrence N; Chin, Lynda.

Cell ; 140(2): 180-2, 2010 Jan 22.

Artigo Inglês | MEDLINE | ID: mdl-20141832

12.

Lineage-specific transcriptional regulation of DICER by MITF in melanocytes.

Levy, Carmit; Khaled, Mehdi; Robinson, Kathleen C; Veguilla, Rosa A; Chen, Po-Hao; Yokoyama, Satoru; Makino, Eiichi; Lu, Jun; Larue, Lionel; Beermann, Friedrich; Chin, Lynda; Bosenberg, Marcus; Song, Jun S; Fisher, David E.

Cell ; 141(6): 994-1005, 2010 Jun 11.

Artigo Inglês | MEDLINE | ID: mdl-20550935

13.

PRKCI promotes immune suppression in ovarian cancer.

Sarkar, Sharmistha; Bristow, Christopher A; Dey, Prasenjit; Rai, Kunal; Perets, Ruth; Ramirez-Cardenas, Alejandra; Malasi, Shruti; Huang-Hobbs, Emmet; Haemmerle, Monika; Wu, Sherry Y; McGuire, Michael; Protopopov, Alexei; Jiang, Shan; Liu, Joyce F; Hirsch, Michelle S; Chang, Qing; Lazar, Alexander J; Sood, Anil K; Drapkin, Ronny; DePinho, Ronald; Draetta, Giulio; Chin, Lynda.

Genes Dev ; 31(11): 1109-1121, 2017 06 01.

Artigo Inglês | MEDLINE | ID: mdl-28698296

14.

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

Genovese, Giannicola; Carugo, Alessandro; Tepper, James; Robinson, Frederick Scott; Li, Liren; Svelto, Maria; Nezi, Luigi; Corti, Denise; Minelli, Rosalba; Pettazzoni, Piergiorgio; Gutschner, Tony; Wu, Chia-Chin; Seth, Sahil; Akdemir, Kadir Caner; Leo, Elisabetta; Amin, Samirkumar; Molin, Marco Dal; Ying, Haoqiang; Kwong, Lawrence N; Colla, Simona; Takahashi, Koichi; Ghosh, Papia; Giuliani, Virginia; Muller, Florian; Dey, Prasenjit; Jiang, Shan; Garvey, Jill; Liu, Chang-Gong; Zhang, Jianhua; Heffernan, Timothy P; Toniatti, Carlo; Fleming, Jason B; Goggins, Michael G; Wood, Laura D; Sgambato, Alessandro; Agaimy, Abbas; Maitra, Anirban; Roberts, Charles W M; Wang, Huamin; Viale, Andrea; DePinho, Ronald A; Draetta, Giulio F; Chin, Lynda.

Nature ; 542(7641): 362-366, 2017 02 16.

Artigo Inglês | MEDLINE | ID: mdl-28178232

15.

miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.

Kouri, Fotini M; Hurley, Lisa A; Daniel, Weston L; Day, Emily S; Hua, Youjia; Hao, Liangliang; Peng, Chian-Yu; Merkel, Timothy J; Queisser, Markus A; Ritner, Carissa; Zhang, Hailei; James, C David; Sznajder, Jacob I; Chin, Lynda; Giljohann, David A; Kessler, John A; Peter, Marcus E; Mirkin, Chad A; Stegh, Alexander H.

Genes Dev ; 29(7): 732-45, 2015 Apr 01.

Artigo Inglês | MEDLINE | ID: mdl-25838542

16.

A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival.

Zheng, Siyuan; Fu, Jun; Vegesna, Rahulsimham; Mao, Yong; Heathcock, Lindsey E; Torres-Garcia, Wandaliz; Ezhilarasan, Ravesanker; Wang, Shuzhen; McKenna, Aaron; Chin, Lynda; Brennan, Cameron W; Yung, W K Alfred; Weinstein, John N; Aldape, Kenneth D; Sulman, Erik P; Chen, Ken; Koul, Dimpy; Verhaak, Roel G W.

Genes Dev ; 27(13): 1462-72, 2013 Jul 01.

Artigo Inglês | MEDLINE | ID: mdl-23796897

17.

PAF promotes stemness and radioresistance of glioma stem cells.

Ong, Derrick Sek Tong; Hu, Baoli; Ho, Yan Wing; Sauvé, Charles-Etienne Gabriel; Bristow, Christopher A; Wang, Qianghu; Multani, Asha S; Chen, Peiwen; Nezi, Luigi; Jiang, Shan; Gorman, Claire Elizabeth; Monasterio, Marta Moreno; Koul, Dimpy; Marchesini, Matteo; Colla, Simona; Jin, Eun-Jung; Sulman, Erik P; Spring, Denise J; Yung, Wai-Kwan Alfred; Verhaak, Roel G W; Chin, Lynda; Wang, Y Alan; DePinho, Ronald A.

Proc Natl Acad Sci U S A ; 114(43): E9086-E9095, 2017 10 24.

Artigo Inglês | MEDLINE | ID: mdl-29073105

18.

Melanoma: from mutations to medicine.

Tsao, Hensin; Chin, Lynda; Garraway, Levi A; Fisher, David E.

Genes Dev ; 26(11): 1131-55, 2012 Jun 01.

Artigo Inglês | MEDLINE | ID: mdl-22661227

19.

STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.

Chen, An-Jou; Paik, Ji-Hye; Zhang, Hailei; Shukla, Sachet A; Mortensen, Richard; Hu, Jian; Ying, Haoqiang; Hu, Baoli; Hurt, Jessica; Farny, Natalie; Dong, Caroline; Xiao, Yonghong; Wang, Y Alan; Silver, Pamela A; Chin, Lynda; Vasudevan, Shobha; Depinho, Ronald A.

Genes Dev ; 26(13): 1459-72, 2012 Jul 01.

Artigo Inglês | MEDLINE | ID: mdl-22751500

20.

Emerging insights into the molecular and cellular basis of glioblastoma.

Dunn, Gavin P; Rinne, Mikael L; Wykosky, Jill; Genovese, Giannicola; Quayle, Steven N; Dunn, Ian F; Agarwalla, Pankaj K; Chheda, Milan G; Campos, Benito; Wang, Alan; Brennan, Cameron; Ligon, Keith L; Furnari, Frank; Cavenee, Webster K; Depinho, Ronald A; Chin, Lynda; Hahn, William C.

Genes Dev ; 26(8): 756-84, 2012 Apr 15.

Artigo Inglês | MEDLINE | ID: mdl-22508724

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