Detalhe da pesquisa
1.
Structural and functional complexity of HSP90 in cellular homeostasis and disease.
Nat Rev Mol Cell Biol
; 24(11): 797-815, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-37524848
2.
Supramolecular assembly of GSK3α as a cellular response to amino acid starvation.
Mol Cell
; 82(15): 2858-2870.e8, 2022 08 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35732190
3.
Experimental traumatic brain injury increases epichaperome formation.
Neurobiol Dis
; 188: 106331, 2023 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-37863370
4.
Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.
Proc Natl Acad Sci U S A
; 117(48): 30670-30678, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33199632
5.
The epichaperome is an integrated chaperome network that facilitates tumour survival.
Nature
; 538(7625): 397-401, 2016 Oct 20.
Artigo
Inglês
| MEDLINE | ID: mdl-27706135
6.
The penalty of stress - Epichaperomes negatively reshaping the brain in neurodegenerative disorders.
J Neurochem
; 159(6): 958-979, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34657288
7.
Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2.
Carcinogenesis
; 41(10): 1421-1431, 2020 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31917403
8.
NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J Biol Chem
; 294(44): 16010-16019, 2019 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31501246
9.
Chaperome heterogeneity and its implications for cancer study and treatment.
J Biol Chem
; 294(6): 2162-2179, 2019 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30409908
10.
Chaperome Networks - Redundancy and Implications for Cancer Treatment.
Adv Exp Med Biol
; 1243: 87-99, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32297213
11.
Structures of Hsp90α and Hsp90ß bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins
; 87(10): 869-877, 2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31141217
12.
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
Blood
; 127(7): 858-68, 2016 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26603836
13.
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
Nature
; 489(7414): 155-9, 2012 Sep 06.
Artigo
Inglês
| MEDLINE | ID: mdl-22820254
14.
Proteomic interrogation of HSP90 and insights for medical research.
Expert Rev Proteomics
; 14(12): 1105-1117, 2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28990809
15.
Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.
Blood
; 126(22): 2479-83, 2015 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-26443624
16.
Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.
Tetrahedron Lett
; 58(48): 4525-4531, 2017 Nov 29.
Artigo
Inglês
| MEDLINE | ID: mdl-30026636
17.
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.
Proc Natl Acad Sci U S A
; 111(50): E5401-10, 2014 Dec 16.
Artigo
Inglês
| MEDLINE | ID: mdl-25516983
18.
RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures.
Nano Lett
; 16(10): 6099-6108, 2016 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27669096
19.
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms.
Blood
; 123(13): 2075-83, 2014 Mar 27.
Artigo
Inglês
| MEDLINE | ID: mdl-24470592
20.
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.
J Labelled Comp Radiopharm
; 59(3): 129-32, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26806023