Social Media Evaluation of Seasonal and Geographic Trends of Corneal Ulcers in the United States.

OBJECTIVES: The purpose of this study is to evaluate if social media and Google search data can identify seasonal and geographic trends in the incidence of corneal ulcers in the United States. METHODS: This is a case series of all corneal ulcer-related data collected from two major social media platforms and Google trends from US users between 2017 and 2021. Instagram and Twitter were searched for posts and hashtags related to "corneal ulcer." Web and image search volume of "corneal ulcer" were collected from Google trends ( https://trends.google.com ). Data were compared between seasons, defined by 3-month intervals, and chi-square tests were used to determine the statistical significance. RESULTS: One hundred and sixty-five individuals (79% female) and 164 individuals (79% female) posted personal new corneal ulcer diagnoses on Twitter and Instagram, respectively. Summer resulted in the highest number of both Twitter (34%, P =0.07) and Instagram (33%, P =0.68) posts. Summer was also the most popular season for Google web and image searches of "corneal ulcer" (search volume average of 58.4 and 41.2, P =0.74 and P =0.01, respectively, with 100 being peak popularity). Across all platforms, the South was the most represented (32% Twitter, 38% Instagram, 32% Google Web, and 33% Google Images). CONCLUSIONS: Our results indicate that social media and Google trends may reflect seasonal and geographic patterns of corneal ulcer incidence in the United States. However, further study with increased power is needed.

Indications for keratoplasty in management of corneal ectasia.

PURPOSE OF REVIEW: The current review aims to describe recent advancements in treatment of corneal ectasias and its effect on indications for corneal transplantation. RECENT FINDINGS: The majority of patients affected by ectatic corneal disease use contact lenses to correct resulting astigmatism. Patients who are intolerant of contact lenses or cannot achieve acceptable vision through conservative measures could consider keratoplasty. However, continuing advancements in both nonsurgical and surgical treatments are either reducing or delaying the need for keratoplasty in patients affected by ectatic corneal disease. SUMMARY: Corneal transplantation has been the mainstay of treatment for patients with advanced ectatic corneal disease. In the past decade, numerous improvements have been occurred to make contact lenses not only more effective for visual correction, but also more comfortable. Although corneal cross-linking is the only proven treatment known to prevent progression of disease, several other therapies show early potential for those in which cross-linking is contraindicated. Patients now have access to a wider range of therapies before considering keratoplasty.

Congenital ankyloblepharon in a newborn with an IRF6 mutation.

We present the case of a boy born at 41 weeks' gestational age who was found to have multiple anatomic anomalies, including abnormalities of the oral cavity, eyelids, and digits. He had ankyloblepharon that was localized to the lateral portion of the palpebral fissure bilaterally. Genetic testing confirmed a mutation in the interferon regulatory factor 6 (IRF6) gene, a known etiology for a spectrum of rare disorders that includes eyelid abnormalities. We present a novel surgical technique for bedside ankyloblepharon repair and describe the relevant clinical features of this case.

Corrigendum #2 to "Eye Manifestations of Shprintzen-Goldberg Craniosynostosis Syndrome: A Case Report and Systematic Review".

[This corrects the article DOI: 10.1155/2020/7353452.].

Eye Manifestations of Shprintzen-Goldberg Craniosynostosis Syndrome: A Case Report and Systematic Review.

Shprintzen-Goldberg craniosynostosis syndrome (SGS) is a rare autosomal dominant condition that was first documented in literature in 1982. The disorder is caused by pathogenic variants in the proto-oncogene SKI gene, a known suppressor of TGF-ß activity, located on chromosome 1p36. There is considerable phenotypic overlap with Marfan and Loeys-Dietz syndromes. Common clinical features of SGS include craniosynostosis, marfanoid habitus, hypotonia, dysmorphic facies, cardiovascular anomalies, and other skeletal and connective tissue abnormalities. Ocular manifestations may include hypertelorism, downslanting palpebral fissures, proptosis, myopia, and ectopia lentis. We describe a 25-year-old male with the syndrome. Genetic analysis revealed a novel c.350G>A (p.Arg117His) de novo variant, which was predicted to be pathogenic by the CTGT laboratory. The patient presented with dysmorphic features, marfanoid habitus, severe joint contractures, mitral valve insufficiency, aortic root dilatation, and a history of seizures. His ocular manifestations included hypertelorism, downslanting palpebral fissures, bilateral ptosis, and high myopia. Ophthalmic manifestations are an integral component of the syndrome; however, they have not been well characterized in the literature. From a systematic review of previously published cases to date, we summarize the eye and ocular adnexa manifestations reported.

Corrigendum to "Eye Manifestations of Shprintzen-Goldberg Craniosynostosis Syndrome: A Case Report and Systematic Review".

[This corrects the article DOI: 10.1155/2020/7353452.].

Effects of Caffeine Consumption by Women and Men on the Outcome of In Vitro Fertilization.

OBJECTIVE: The objective of this study was to estimate the association between caffeine consumption and in vitro fertilization (IVF) outcomes. METHODS: A total of 2474 couples were prospectively enrolled prior to undergoing their first cycle of IVF, contributing a total of 4716 IVF cycles. Discrete survival analysis adjusting for observed confounders was applied to quantify the relation between caffeine consumption and livebirth. Secondary outcomes of interest were oocyte retrieval, peak estradiol level, implantation rate, and fertilization rate. RESULTS: Overall, caffeine consumption by women was not significantly associated with livebirth (ptrend=0.74). Compared with women who do not drink caffeine, the likelihood of livebirth was not significantly different for women who drank low (>0-800 mg/week; odds ratio [OR]=1.00, 95% confidence interval [CI])=0.83-1.21), moderate (>800-1400 mg/week; OR=0.89, 95% CI=0.71-1.12), or high levels of caffeine (>1400 mg/week; OR=1.07, 95% CI=0.85-1.34). Greater caffeine intake by women was associated with a significantly lower peak estradiol level (ptrend=0.03), but was not associated with the number of oocytes retrieved (ptrend=0.75), fertilization rate (ptrend=0.10), or implantation rate (ptrend=0.23). There was no significant association between caffeine intake by men and livebirth (ptrend=0.27), fertilization (ptrend=0.72), or implantation (ptrend=0.24). The individual effects of consumption of coffee, tea, or soda by women or men were not related to livebirth. CONCLUSION: Caffeine consumption by women or men was not associated with IVF outcomes.