Conservation agriculture works as a catalyst for sustainable sodic soil reclamation and enhances crop productivity and input use efficiency: A scientific inquiry.

Soil sodicity is a growing concern for crop growth and development in arid and semi-arid regions of the world. Conservation agriculture (CA) provides an effective solution towards reclamation of degraded sodic lands and enhance the crop productivity. A field experiment was carried out to assess the sodic soil reclamation potential of CA based management practices including zero tillage, legume (mungbean; Mb) rotation, residue (+R) mulch, and subsurface drip irrigation (SDI) for three years under rice-wheat (RW) system. The system scenarios (Sc) comprised of multiple indicators to measure their impact on soil properties as well as system productivity, profitability, water and nitrogen use efficiency. The results indicated that soil pHs under Sc5-Sc8 (CA-based SDI scenarios) was significantly (p < 0.05) lowered by 2.16, 2.16 and 1.33% compare with mean of Sc1 and Sc2 (CT-based system; 9.10, 8.29 and 8.14) at all three soil layers (0-5, 5-15 and 15-30 cm), respectively. Similarly, the exchangeable sodium percentage (ESP) was lowered by 2.9, 11.2 and 14.9% under CA-based scenarios with residue management compared with CT-based system (mean of Sc1 and Sc2; 15.2, 17.2 and 28.6%) during the study. The concentration of extractable anions (COЗ2‾, HCOЗ‾, Cl‾) decreased notably whereas, soil organic carbon and soil solution cations (Na+, Ca2+, Mg2+) concentration were increased under CA based management SDI plots. In addition, CA with SDI scenarios (mean of Sc5-Sc8) proved to be more productive and water-efficient than CA-based flood irrigation (FI; mean of Sc3 and Sc4). Moreover, CA-based FI and SDI scenarios saved 29.5 and 60.7% irrigation water, and improved the partial factor productivity of nitrogen (PFPN) by 6.8 and 24.4%, respectively compared to CT-R (conventional tillage without residue) based Sc1. Therefore, CA practices can potentially reduce sodicity and improve soil chemical properties for profitable crop cultivation.

The Current Pipeline of Antiretroviral Therapy: Expanding Options and Filling Gaps.

Highly effective antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) care in the past 3 decades. 30 years ago, how many would have imagined that a single-tablet daily ART regimen containing different drug classes could achieve sustained HIV-1 suppression and halt disease progression to acquired immunodeficiency syndrome (AIDS)? Despite this remarkable achievement, challenges in HIV care remain that require further innovation for ART. In this review, we focus on newly approved antiretroviral agents and those undergoing phase 2/3 clinical trials. These new antiretrovirals hold great promise to expand treatment options and fill gaps in HIV care.