Detalhe da pesquisa
1.
Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.
Cell
; 157(7): 1565-76, 2014 Jun 19.
Artigo
Inglês
| MEDLINE | ID: mdl-24949969
2.
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
J Immunol
; 191(7): 3568-77, 2013 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24006460
3.
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.
Sci Transl Med
; 15(683): eabj3289, 2023 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36791209
4.
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.
PLoS Pathog
; 6(9): e1001100, 2010 Sep 09.
Artigo
Inglês
| MEDLINE | ID: mdl-20844580
5.
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.
PLoS Pathog
; 5(10): e1000645, 2009 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-19876393
6.
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 64(9): 6037-6058, 2021 05 13.
Artigo
Inglês
| MEDLINE | ID: mdl-33939425
7.
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
J Med Chem
; 64(6): 2937-2952, 2021 03 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33719441
8.
Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.
J Med Chem
; 64(19): 14557-14586, 2021 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34581584
9.
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
J Med Chem
; 63(22): 13526-13545, 2020 11 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32902984
10.
Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators.
Front Pharmacol
; 10: 514, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31143125
11.
Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent.
J Med Chem
; 61(4): 1425-1435, 2018 02 22.
Artigo
Inglês
| MEDLINE | ID: mdl-29148763
12.
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 60(9): 3580-3590, 2017 05 11.
Artigo
Inglês
| MEDLINE | ID: mdl-28414242
13.
Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
J Med Chem
; 60(17): 7371-7392, 2017 09 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28731719
14.
Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.
J Med Chem
; 57(22): 9323-42, 2014 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-25369270
15.
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem
; 57(23): 10044-57, 2014 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25380412
16.
Identification of a novel sulfonamide non-nucleoside reverse transcriptase inhibitor by a phenotypic HIV-1 full replication assay.
PLoS One
; 8(7): e68767, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23874756
17.
Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.
J Med Chem
; 61(9): 4270, 2018 05 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29672037
18.
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.
Nat Med
; 19(9): 1157-60, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23913123
19.
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.
J Med Chem
; 55(14): 6391-402, 2012 Jul 26.
Artigo
Inglês
| MEDLINE | ID: mdl-22738293
20.
Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors.
J Med Chem
; 55(1): 68-83, 2012 Jan 12.
Artigo
Inglês
| MEDLINE | ID: mdl-22098589