Detalhe da pesquisa
1.
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.
J Am Chem Soc
; 140(21): 6596-6603, 2018 05 30.
Artigo
Inglês
| MEDLINE | ID: mdl-29668265
2.
Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J Am Chem Soc
; 139(9): 3528-3536, 2017 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28230359
3.
Glycomimetic ligands for the human asialoglycoprotein receptor.
J Am Chem Soc
; 134(4): 1978-81, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22280495
4.
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.
Nat Struct Mol Biol
; 14(2): 106-13, 2007 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-17237796
5.
Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection.
J Lipid Res
; 51(5): 967-74, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-19965592
6.
Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein.
Bioconjug Chem
; 19(8): 1604-13, 2008 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-18646836
7.
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Nat Commun
; 8(1): 1908, 2017 12 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29199275
8.
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
J Med Chem
; 60(18): 7835-7849, 2017 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28853885
9.
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Sci Rep
; 6: 30859, 2016 08 16.
Artigo
Inglês
| MEDLINE | ID: mdl-27527709
10.
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Sci Rep
; 6: 26071, 2016 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-27184415
11.
Discovery and structural characterization of an allosteric inhibitor of bacterial cis-prenyltransferase.
Protein Sci
; 24(1): 20-6, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25287857
12.
Crystal structures of interleukin 17A and its complex with IL-17 receptor A.
Nat Commun
; 4: 1888, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23695682
13.
Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J Biol Chem
; 284(19): 13193-201, 2009 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-19244237
14.
Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.
J Med Chem
; 52(11): 3576-85, 2009 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-19438227
15.
A thermally sensitive loop in clostridial glutamate dehydrogenase detected by limited proteolysis.
J Biol Chem
; 278(2): 1067-74, 2003 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-12414808
16.
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.
Bioorg Med Chem Lett
; 13(3): 379-82, 2003 Feb 10.
Artigo
Inglês
| MEDLINE | ID: mdl-12565933