Role of anthropometric characteristics in idiopathic carpal tunnel syndrome.

OBJECTIVE: To investigate the possible association of external and ultrasonographic measurements of the hand and wrist with median nerve conduction studies. DESIGN: Two group comparison study. SETTING: Outpatient neurophysiology laboratory and radiology department in a university hospital. PARTICIPANTS: Patient group (n=50; 40 women) with clinically overt and electrophysiologically proven idiopathic carpal tunnel syndrome and a control group of age- and sex-matched healthy volunteers (n=50). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The following measurements were taken: (1) motor and sensory conduction studies of the median nerve; (2) external hand and wrist dimensions (hand ratio and wrist ratio); and (3) ultrasonographic dimensions of the carpal tunnel (carpal tunnel inlet ratio and carpal tunnel outlet ratio) and inlet cross-sectional area and outlet cross-sectional area of the median nerve at the tunnel. RESULTS: Differences between patients and controls were significant for hand and wrist ratios and all ultrasonographic dimensions. Sensory conduction velocity and distal motor latency of the median nerve in all 100 subjects were well correlated with hand ratio, wrist ratio, carpal tunnel inlet ratio, and carpal tunnel outlet ratio estimates. Wrist ratio was significantly correlated with carpal tunnel inlet ratio and carpal tunnel outlet ratio. CONCLUSIONS: A particular hand and wrist configuration, that is, short and wide hand with square wrist matching to narrow and deep tunnel entrance demonstrated increased liability for idiopathic carpal tunnel syndrome. For screening purposes, it was suggested that simple external hand or wrist measurements could be used to predict the tendency for carpal tunnel syndrome.

Occurrence of bifid median nerve in healthy and carpal tunnel syndrome patients.

We investigated the possible association between median nerve morphology and carpal tunnel size, hand side and nerve conduction measurements. The study included a patient group (n = 58; 44 women) with idiopathic carpal tunnel syndrome (CTS) in 100 hands and a control group of healthy volunteers (n = 56, 112 hands; 44 women). The following data were recorded: (1) median and ulnar motor and sensory nerve conduction parameters (2) ultrasonographic dimensions of the carpal tunnel inlet area (CTAin) and inlet area of the median nerve. The prevalence of bifid median nerve was 19% in the CTS hands and 13.3% in the control group. Bilateral bifid nerve was detected in 7 subjects and unilateral in 23, with no side or sex preponderance. The median nerve area was larger in the participants with single than those with bifid median nerve. No correlation was found between CTAin and median nerve area for single or bifid nerves in controls or patients. It was concluded that bifid median nerve was not a rare variation. We could not, however, support its etiological relation to CTS. Ultrasonographic examination of the carpal tunnel region supplementing neurophysiology provided a reliable means to detect median nerve size and morphology. CLINICAL TRIAL REGISTRATION NUMBER: 84; 5/3/15.

Risk for transient ischemic attacks is mainly determined by intima-media thickness and carotid plaque echogenicity.

BACKGROUND: Stenosis severity, plaque morphology, and intima-media thickness (IMT), all have been found to provide prognostic information in patients with asymptomatic carotid artery disease. However, limited data exist on the association between these parameters and the risk for transient ischemic attack (TIA). METHODS: We compared the ultrasonographic characteristics of 88 consecutive patients with first TIA without known cardioembolic source with those of 176 propensity-matched asymptomatic control subjects. RESULTS: IMT was higher in TIA patients compared to control subjects (0.74+/-0.14 mm versus 0.68+/-0.13 mm, p=0.001). Plaques were found in 70.5% of patients and 64.8% of controls (p=0.407). Compared with controls, TIA patients demonstrated more frequently predominantly echolucent lesions (77.4% versus 56.1%, p=0.005) and high-grade carotid stenoses (21.0% versus 9.6%, p=0.042). TIA patients with low-to-moderate grade (<70%) lesions exhibited higher IMT and more prevalent echolucent morphology in comparison with their control counterparts. No significant differences were observed between groups regarding high-grade lesions. In multivariate models, IMT and plaque echogenicity, but not stenosis severity, emerged as independent determinants of risk. CONCLUSIONS: Risk for TIA is primarily associated with IMT and plaque echogenicity, especially in the absence of high-grade lesions. Stenosis severity appears to be of limited prognostic value.

Trends and future needs in clinical radiology: insights from an academic medical center.

OBJECTIVE: Advances in technology, expanding indications and defensive medical practice, in combination with population aging, have all contributed to a substantial increase in utilization of imaging and therapeutic radiology procedures in recent years. Moreover, the integration of education, innovation and research into high-volume workflow, although challenging, is a key requirement in teaching hospitals. Therefore, identifying forthcoming demand in the use of radiology services at a referral center might be of special interest and facilitate health policy planning in this context. METHODS: Data regarding conventional radiographic, ultrasonographic and computed tomography (CT) investigations, radiotherapy sessions, and interventional procedures were collected for a 5-year period (2000-2004). Based on these observations, we deployed appropriate models to forecast utilization rates in 2005-2009. RESULTS: Between 2000 and 2004, ultrasound examinations increased by 31.8%, mammography by 31.6%, CT scans by 17.4%, interventions by 14.5% and radiotherapy sessions by 13.9%, while conventional investigations decreased by 42.5%. We identified significant increasing trends for ultrasound, mammography, CT and interventions (all p<0.001 for linear component). Compared to current levels, the workload for these modalities is expected to rise in the next 5 years by 43%, 31%, 20% and 14%, respectively. Radiotherapy sessions demonstrate an unstable, non-significant increasing trend (p=0.189), while utilization of conventional radiography declines rapidly (p<0.001 for linear trend, 5-year prediction -51%). CONCLUSIONS: In forthcoming years, the demand for radiology services at referral centers will increase substantially. Advances in digital technology alone will not suffice to completely alleviate the need for additional resources and well-trained personnel.

Global vasomotor dysfunction and accelerated vascular aging in beta-thalassemia major.

BACKGROUND: Patients with beta-thalassemia major (beta-TM) demonstrate an increased incidence of vascular complications, which are thought to result from a procoagulant/proinflammatory environment. We investigated the arterial vasorelaxing capacity and sought for early carotid atherosclerosis and underlying pathophysiological correlates in these transfusion-dependent patients. METHODS AND RESULTS: The vasodilatory properties of the brachial artery and the carotid intima-media thickness (IMT) were examined with ultrasonography in 35 non-diabetic young adults with beta-TM (patient group) and 35 control subjects (control group). Among thalassemic patients, both endothelium-dependent (FMD) and -independent dilatation (FID) as well as their ratio was impaired, whereas IMT was increased (p<0.01). Patients on optimal, as compared with those on non-optimal chelation treatment had a non-significantly lower IMT. Vasodilatory capacity in the patient group was inversely correlated with IMT and independently associated either with the quality of chelation therapy (FMD) or serum ferritin levels (FID). Plasma concentrations of D-dimers, circulating markers of endothelial activation, inflammation and apoptosis were higher, while plasma cholesterol and fibrinogen levels were lower-than-normal in the patient group. Independent predictors of IMT among thalassemic patients were tumor necrosis factor-alpha levels and age. CONCLUSIONS: Young adults with beta-TM exhibit both a global impairment of arterial vasorelaxation and early carotid atherosclerosis. A procoagulant/proinflammatory state in these transfusion-dependent patients may overwhelm atheroprotective mechanisms, including an optimal chelation regimen, and promote vascular injury and atherogenesis.