Correlation of toxoplasmosis with small­for­gestational­age newborns.

BACKGROUND: Toxoplasma gondii infection in pregnant women could lead to significant changes during the pregnancy, affect the outcomes of pregnancy and the timing of labour. Small­for­gestational­age (SGA) newborns are defined by birthweight below the 10th percentile for gestational age. We tested an association between latent toxoplasmosis in pregnant women and deliveries of SGA babies. MATERIAL AND METHODS: For testing, we included 1,647 women who gave birth to a singleton baby at ≥ 37 weeks of gestation. The complement-fixation test (CFT) and enzyme-linked immunosorbent assay (ELISA) tests for IgG and IgM were used. The latent form of toxoplasmosis was defined as a CFT titre of 1:8 or higher, together with index positivity IgG ELISA > 1.1 and negative IgM. RESULTS: There were 406 (24.7 %) women positive, and 1,241 (75.3 %) women negative for latent toxoplasmosis. Of all deliveries. 190 were SGA­positive and 1,457 were SGA­negative. Our study found a statistically significant association between latent toxoplasmosis and SGA foetuses born at term. The Pearson chi-square model was statistically significant (χ2(1) = 7.365, p = .007). The odds ratio was 1.567. CONCLUSION: Pregnant women with latent toxoplasmosis giving birth at ≥ 37 weeks of gestation have a 1.567 times higher risk of delivering an SGA baby (Tab. 2, Fig. 1, Ref. 30).

Evaluation of the safety of palivizumab in the second season of exposure in young children at risk for severe respiratory syncytial virus infection.

BACKGROUND: Palivizumab reduces respiratory syncytial virus (RSV) hospitalisations in high-risk infants. Those with severe bronchopulmonary dysplasia may require two seasons of prophylaxis. There is concern that this humanised antibody might cause an adverse immune response in a second season of use. OBJECTIVE: To evaluate and compare the occurrence of anti-palivizumab antibodies and clinical adverse events in subjects receiving monthly palivizumab injections for a first and second season, and to assess frequency and severity of RSV disease in the two groups. DESIGN AND PATIENTS: Subjects aged or=1 : 80). Serum palivizumab concentrations were similar for the two groups. Nine (12.7%) first season and 8 (12.7%) second season subjects experienced one or more serious adverse events; most were respiratory and all were considered to be not or probably not related to palivizumab. No deaths occurred during the study. CONCLUSIONS: Monthly palivizumab injections were not associated with adverse immune responses or adverse events in young children receiving palivizumab for one or two seasons. Children receiving palivizumab for a second season did not experience more severe adverse events than those receiving it for the first time.

Slide plasty of trachea and right main bronchus in a newborn.

Congenital stenosis of airways is a rare and possibly life-threatening congenital defect with difficult treatment and uncertain prognosis. In our report, we describe a rare case of a 1-month-old newborn with concomitant stenosis of trachea and main bronchus and its successful treatment using slide plasty.

Attitudes of stakeholders towards the Podyji/Thaya River Basin National Park in the Czech Republic.

In August 2000, a survey of public opinion was carried out among visitors, local residents and representatives of local self-governments in the territory of the Podyji/Thaya River Basin National Park in the Czech Republic. The goal was to obtain stakeholders' opinions and attitudes towards nature conservation, the National Park and tourism within the territory which used to be closed to the public for 40 years due to the Iron Curtain. Without the knowledge of opinions of stakeholders it is not possible to manage nature conservation and development in the protected area properly. Using the method of direct interviews, 646 questionnaires where collected, of which 523 were from visitors and tourists, 115 from local residents and 8 from mayors of towns/villages. The questionnaires were analysed in order to detect differences in attitudes among the respondent groups in the following thematic areas: (a) the National Park, its environment and perception of it by respondents; (b) relationship of respondents to the territory; (c) tourism and attitudes towards recreational activities; (d) the Administration of the National Park and evaluation of its work; and (e) economic impact of tourism for local communities. One section of the study focused on comparing the attitudes between local inhabitants and mayors and the other section presents a collation of opinions from locals, mayors and tourists. Although a positive evaluation of the national park dominated the results, some negative attitudes and experiences were identified among locals. In addition, the situation also differed within communities. Results also indicated a relatively strong relationship to the territory by locals, but low job opportunities and income from tourism. The level of tourism intensity was perceived as an increasing and sometimes disturbing factor for local communities; motoring was observed as being the most negative activity for nature. The Administration of the Podyji/Thaya River Basin National Park was sometimes criticised and the communication with the community was not always evaluated satisfactorily. All groups of respondents identified waste management to be the most pressing issue. Identification of differences in attitudes of interviewed respondents may be effectively used in planning environmental management and sustainable tourism development in the area.