RESUMO
Few cases of myopathy have been reported in patients treated with ezetimibe as monotherapy or in association with a statin. We report on two cases of elevation of CKP that occurred upon monotherapy with ezetimibe, which were reversible after discontinuation of the drug. In both cases, patients previously experienced intolerance with other lipid-lowering agents. The pathogenesis of muscle toxicity associated with ezetimibe is not known yet. An interaction with statin or a toxicity mechanism common to several lipid-lowering drugs have been suggested. A potential role of induction of glucuronidation by numerous associated drugs can also be involved Although association of ezetimibe with myopathy seems to be uncommon, special attention should be given to patients treated with ezetimibe who had a previous intolerance to other lipid-lowering drugs and who received several drugs.
Assuntos
Anticolesterolemiantes/uso terapêutico , Azetidinas/uso terapêutico , Creatina Quinase/sangue , Diabetes Mellitus Tipo 2/tratamento farmacológico , Creatina Quinase/efeitos dos fármacos , Creatinina/sangue , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/enzimologia , Ezetimiba , Feminino , Fenofibrato/uso terapêutico , Hemoglobinas Glicadas/análise , Humanos , Falência Renal Crônica/sangue , Masculino , Pessoa de Meia-IdadeRESUMO
We report on a child with bilateral anophthalmia, esophageal atresia, and cryptorchidism. This is the first case observed in the Spanish Collaborative Study of Congenital Malformations (ECEMC) with this constellation of congenital anomalies, and it is similar to that described in 1988 by Rogers. We think that it may constitute a new syndrome.
Assuntos
Anoftalmia/complicações , Criptorquidismo/complicações , Atresia Esofágica/complicações , Anoftalmia/diagnóstico , Criptorquidismo/diagnóstico , Atresia Esofágica/diagnóstico , Atresia Esofágica/cirurgia , Humanos , Recém-Nascido , Masculino , SíndromeRESUMO
We measured urinary albumin excretion in 2,224 school-children (1,168 boys, 1,056 girls) aged 2-18 years, between 1989 and 1990 to establish reference values. We recorded all pathological antecedents and findings from physical examination, including anthropometric parameters and arterial blood pressure. The analytical study included serum total protein, albumin and creatinine. The second-morning urine and the nightly (rest) 10-h urine sample were collected and we determined the concentration of albumin and creatinine. We found a positive statistically significant correlation between the urinary albumin excretion (micrograms/10 h) and age, height, weight and body surface area. We suggest that it would be useful to relate the urinary albumin excretion to body surface area. The mean value for albumin excretion was 3.49 micrograms/ml in boys and 3.63 micrograms/ml in girls. The urinary albumin/creatinine ratio showed a high correlation with the albumin excretion (r = 0.958).