RESUMO
A 66-year-old man reported a slowly growing tumor on the lateral edge of his left upper eyelid. This lesion was hard but movable on palpation. A neoplasm of the lacrimal gland was suspected. CT showed a highly calcified lesion at the left upper eyelid. Resection of the tumor was performed, which was located just behind the orbital septum and in front of the lacrimal gland. Anatomopathologic investigation of the excised specimen with immunohistochemistry revealed a benign meningioma of a meningotheliomatous type, containing multiple bone elements. An ectopic orbital meningioma is rare, and this is the first case of a unique lateral localization of this lesion. Therefore, it should be included in the differential diagnosis of a lacrimal gland tumor.
Assuntos
Coristoma/diagnóstico por imagem , Aparelho Lacrimal/diagnóstico por imagem , Neoplasias Meníngeas , Meningioma , Neoplasias Orbitárias/diagnóstico por imagem , Idoso , Coristoma/patologia , Coristoma/cirurgia , Humanos , Imuno-Histoquímica , Aparelho Lacrimal/patologia , Masculino , Mucina-1/análise , Neoplasias Orbitárias/química , Neoplasias Orbitárias/patologia , Neoplasias Orbitárias/cirurgia , Ossificação Heterotópica/patologia , Tomografia Computadorizada por Raios X , Vimentina/análiseRESUMO
We investigated the corneal precipitate of a 6-year-old boy with vernal keratoconjunctivitis (VKC), treated with topical ofloxacin 0.3% eyedrops. Because of the extremely small sample amount (corneal scraping), a very sensitive and specific method was needed with the possibility of an unambiguous identification of ofloxacin, supposed to be present in the precipitate. In this respect, tandem Q-TOF mass spectrometry combined with micro LC (1 mm I.D.) was chosen. Confirmation of the presence of ofloxacin in the deposit was obtained by means of the characteristic product ion spectrum produced by CID. This clearly indicated that the precipitate, removed by corneal scraping from the 6-year-old boy with VKC, contained ofloxacin.