Detalhe da pesquisa
1.
Antiviral Properties of HIV-1 Capsid Inhibitor GSK878.
Antimicrob Agents Chemother
; 67(5): e0169422, 2023 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37039636
2.
GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile.
Antimicrob Agents Chemother
; 66(1): e0187621, 2022 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34780263
3.
Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A.
Nature
; 527(7577): 245-8, 2015 Nov 12.
Artigo
Inglês
| MEDLINE | ID: mdl-26536115
4.
GSK3732394: a Multi-specific Inhibitor of HIV Entry.
J Virol
; 93(20)2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31375580
5.
A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin.
J Virol
; 92(14)2018 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29743355
6.
Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.
PLoS Pathog
; 12(11): e1005990, 2016 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-27893830
7.
Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28584151
8.
Functionalized triazines as potent HCV entry inhibitors.
Bioorg Med Chem Lett
; 27(4): 1089-1093, 2017 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28089701
9.
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Antimicrob Agents Chemother
; 60(7): 3956-69, 2016 07.
Artigo
Inglês
| MEDLINE | ID: mdl-27090171
10.
Synergistic Activity of Combined NS5A Inhibitors.
Antimicrob Agents Chemother
; 60(3): 1573-83, 2015 Dec 28.
Artigo
Inglês
| MEDLINE | ID: mdl-26711745
11.
Combating antimicrobial resistance in malaria, HIV and tuberculosis.
Nat Rev Drug Discov
; 23(6): 461-479, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38750260
12.
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.
Cancer Cell
; 7(4): 325-36, 2005 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-15837622
13.
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
J Med Chem
; 66(3): 1941-1954, 2023 02 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36719971
14.
A novel small molecule inhibitor of hepatitis C virus entry.
PLoS Pathog
; 6(9): e1001086, 2010 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-20838466
15.
Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc.
AIDS
; 36(1): 11-18, 2022 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34628442
16.
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
J Med Chem
; 65(18): 11927-11948, 2022 09 22.
Artigo
Inglês
| MEDLINE | ID: mdl-36044257
17.
Transcriptional profiling of the dose response: a more powerful approach for characterizing drug activities.
PLoS Comput Biol
; 5(9): e1000512, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19763178
18.
Interview with Dr. Mark Cockett: current trends in screening for antiviral therapeutics. Interviewed by Nina N. Brahme and Devin J. Noblin.
Yale J Biol Med
; 83(4): 235-40, 2010 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21165343
19.
Chemical genetics reveals an RGS/G-protein role in the action of a compound.
PLoS Genet
; 2(4): e57, 2006 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-16683034
20.
Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study.
PLoS One
; 14(10): e0224076, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31622432