Detalhe da pesquisa
1.
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.
J Med Virol
; 94(12): 5975-5986, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35949003
2.
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators.
Molecules
; 27(23)2022 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36500508
3.
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction.
Molecules
; 27(18)2022 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36144727
4.
Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators.
Molecules
; 27(21)2022 Nov 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36364467
5.
Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.
Bioorg Med Chem
; 48: 116414, 2021 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34562701
6.
Recent Advances in HIV-1 Gag Inhibitor Design and Development.
Molecules
; 25(7)2020 Apr 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32272714
7.
Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability.
Molecules
; 25(6)2020 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32245167
8.
Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor.
Molecules
; 24(8)2019 Apr 22.
Artigo
Inglês
| MEDLINE | ID: mdl-31013646
9.
Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding.
J Biol Chem
; 292(45): 18392-18407, 2017 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28939772
10.
IgG Binding Characteristics of Rhesus Macaque FcγR.
J Immunol
; 197(7): 2936-47, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27559046
11.
The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding.
Biochem J
; 474(21): 3689-3704, 2017 10 25.
Artigo
Inglês
| MEDLINE | ID: mdl-28935721
12.
Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.
Nucleic Acids Res
; 44(9): 4189-99, 2016 05 19.
Artigo
Inglês
| MEDLINE | ID: mdl-26873923
13.
Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency.
Molecules
; 23(8)2018 Aug 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30081466
14.
Insertion of perilipin 3 into a glycero(phospho)lipid monolayer depends on lipid headgroup and acyl chain species.
J Lipid Res
; 57(8): 1465-76, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27256689
15.
Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.
Bioorg Med Chem Lett
; 26(1): 228-34, 2016 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26531151
16.
Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.
Bioorg Med Chem Lett
; 26(3): 824-828, 2016 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-26747394
17.
High-resolution crystal structure reveals molecular details of target recognition by bacitracin.
Proc Natl Acad Sci U S A
; 110(35): 14207-12, 2013 Aug 27.
Artigo
Inglês
| MEDLINE | ID: mdl-23940351
18.
The high resolution structure of tyrocidine A reveals an amphipathic dimer.
Biochim Biophys Acta
; 1838(5): 1199-207, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24530898
19.
Analysis of the activities of RAD54, a SWI2/SNF2 protein, using a specific small-molecule inhibitor.
J Biol Chem
; 288(44): 31567-80, 2013 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24043618
20.
An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo.
Infect Immun
; 82(10): 4080-91, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25024365