RESUMO
OBJECTIVES: This open, single-cohort, multicenter, prospective study investigated the efficacy of immediately provisionalized tapered conical connection implant for single-tooth restorations in the anterior and premolar regions of the maxilla after 5 years of function. MATERIALS AND METHODS: All implants were placed in healed sites and immediately provisionalized. MBLs, soft-tissue parameters, and oral-health impact profile (OHIP) were evaluated at implant insertion, 6, 12, 24, 36, and 60 months. Paired Wilcoxon signed-rank tests and Kaplan-Meier survival analysis was used for statistical and implant survival/success analyses, respectively. RESULTS: Seventy-seven patients (81 implants) completed the 5-year follow-up. The 5-year cumulative survival and success rates were 97.8%, and the mean MBL change from implant insertion to 5 years was - 0.80 ± 1.13 mm. Optimal papilla index scores were observed at 90.1% of sites at 5 years compared with 32.8% of sites at insertion. Pink esthetic score, modified bleeding and plaque indices, and OHIP showed statistically significant improvement at the 5-year follow-up. CONCLUSIONS: Immediately provisionalized tapered conical connection implants promote marginal bone stability and excellent esthetic outcomes after 5 years of function. CLINICAL RELEVANCE: This treatment is a viable option for patients requiring immediately provisionalized single-tooth restorations in the esthetic zone and shows favorable long-term clinical outcomes, including marginal bone stability and excellent esthetics.
Assuntos
Implantes Dentários para Um Único Dente , Implantes Dentários , Carga Imediata em Implante Dentário , Planejamento de Prótese Dentária , Estética Dentária , Seguimentos , Humanos , Maxila/cirurgia , Estudos Prospectivos , Resultado do TratamentoRESUMO
OBJECTIVES: Sutures are the most frequently used medical device for wound closure. They support tissue during the early phase of healing until it regains enough tensile strength. The aim of this study was to compare four different suture materials in terms of the influence on wound healing, microbial adherence, tissue reaction, and relevant clinical parameters which determine their clinical value. MATERIALS AND METHODS: Total number of 32 patients undergoing surgical extraction of four impacted third molars were involved in the study. Clinical parameters were estimated intraoperatively and during the control check-ups. Soft tissue healing around sutures were evaluated on the 3rd and 7th day postoperatively. Microbial colonization was assessed by means of qPCR. Also, histological analysis was done to assess inflammatory reaction. RESULTS: Significantly better soft tissue healing was found around monofilament and synthetic sutures compared to multifilament and natural ones respectively. Soft tissue healing was significantly better around all sutures on the 7th day than on the 3rd day postoperatively. CONCLUSIONS: Non-resorbable polypropylene suture showed superior clinical characteristics among all sutures. Moreover, the best healing of soft tissue and the least inflammatory reaction was found around this thread. The poorest soft tissue healing was found around non-resorbable silk suture. This suture elicited strongest inflammatory reaction and showed the greatest microbial adherence affinity compared to alternative sutures. CLINICAL RELEVANCE: Monofilament synthetic suture should be used in order to obtain the best soft tissue healing, reduce the risk of postoperative infection, and alleviate the suturing after oral surgery procedures.
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Procedimentos Cirúrgicos Bucais , Polipropilenos , Seda , Infecção da Ferida Cirúrgica/prevenção & controle , Suturas , Cicatrização , Humanos , Técnicas de Sutura/instrumentação , Resistência à TraçãoRESUMO
OBJECTIVES: Genetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts. MATERIAL AND METHODS: Current study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232). A case-control study was conducted on 41 keratocyst cases, 43 radicular cyst cases, and control group of 93 healthy individuals without cystic lesions, radiographically confirmed. Single-nucleotide polymorphisms were assessed by real-time and TaqMan SNP genotyping assays, while PTCH1 insertion 18 bp IVS1-83 polymorphism was determined by PCR. RESULTS: The difference in genotype distribution between keratocyst cases and control group was observed for PTCH1 IVS1-83 and GLI1 rs2228224 polymorphism (p = 0.022, p = 0.030, respectively). Homozygous mutant GG genotype within GLI1 rs2228224 is associated with increased susceptibility for odontogenous keratocysts, with adjusted odds ratio of 4.098 (confidence interval of 1.482-11.328, p = 0.007). CONCLUSION: GLI1 rs2228224 and PTCH1 polymorphisms could predispose to odontogenic keratocysts. CLINICAL RELEVANCE: Variants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions and potential targets for novel therapeutic approaches.
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Proteínas Hedgehog/genética , Cistos Odontogênicos/genética , Receptores de Calcitriol/genética , Transdução de Sinais , Estudos de Casos e Controles , Humanos , Receptor Patched-1/genética , Polimorfismo de Nucleotídeo Único , Fatores de Risco , Receptor Smoothened/genética , Proteína GLI1 em Dedos de Zinco/genéticaRESUMO
OBJECTIVES: This multicenter prospective clinical trial investigated immediately provisionalized, anodized, conical connection, tapered implants with platform shifting in maxillary anterior and premolar sites. MATERIALS AND METHODS: Patients requiring single-tooth implant-supported restorations in maxillary anterior and premolar sites were enrolled. Implants were immediately provisionalized and evaluated at insertion, 6 months, and annually thereafter. Outcome measures were marginal bone level change (ΔMBL), cumulative survival rate (CSR), and success rate, soft-tissue parameters, and oral health impact profile (OHIP). ΔMBL and Pink Esthetic Score were analyzed using Wilcoxon signed-rank tests. CSR was calculated using life table analysis. Other soft-tissue parameters were analyzed using sign tests. RESULTS: Of 94 enrolled patients (99 implants), 84 (88 implants) attended the 3-year follow-up. After an initial bone loss between implant insertion and 6 months (- 0.92 ± 1.23 mm), bone levels stabilized from 6 months to 3 years (0.13 ± 0.94 mm) with no significant change. The 3-year CSR was 98.9%, and the cumulative success rate was 96.9%. Papilla index scores of 2 or 3 were observed at 88.6% of sites at the 3-year visit compared with 32.8% at implant insertion. Improvements were observed for all other outcomes, including bleeding on probing, esthetics, plaque, and OHIP. CONCLUSIONS: This restorative protocol was associated with high primary stability, patient satisfaction, stable bone levels, and an overall improvement of the soft tissue outcomes over a 3-year period. CLINICAL RELEVANCE: The presented treatment is a viable option for single-tooth restorations of maxillary anterior teeth and premolars with successful short- to mid-long-term clinical outcomes.
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Implantes Dentários , Carga Imediata em Implante Dentário , Adolescente , Adulto , Idoso , Dente Pré-Molar , Estética Dentária , Feminino , Seguimentos , Humanos , Masculino , Maxila , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento , Adulto JovemRESUMO
OBJECTIVES: The aim of this multicenter prospective clinical study was to evaluate anodized tapered implants with a conical connection and integrated platform shifting placed in the anterior and premolar maxilla. MATERIALS AND METHODS: The study enrolled patients requiring single-tooth restorations in healed sites of maxillary anterior and premolar teeth. All implants were immediately temporized. Clinical and radiographic evaluations were conducted at implant insertion, 6 months, and 1 year. Outcome measures included bone remodeling, cumulative survival rate (CSR), success rate, soft-tissue health and esthetics, and patient satisfaction. Bone remodeling and pink esthetic score were analyzed using Wilcoxon signed-rank tests. CSR was calculated using life table analysis. Other soft-tissue outcomes were analyzed using sign tests. RESULTS: Out of 97 enrolled patients (102 implants), 87 patients (91 implants) completed the 1-year visit. Marginal bone remodeling was -0.85 ± 1.36 mm. After the expected initial bone loss, a mean bone gain of 0.11 ± 1.05 mm was observed between 6 months and 1 year. The CSR was 99.0%, and the cumulative success rate was 97.0%. Partial or full papilla was observed at 30.8% of sites at baseline, 87.2% at 6 months, and 90.5% at 1 year. Soft-tissue response, esthetics, and patient satisfaction all improved during the study period. CONCLUSIONS: Bone gain was observed following the expected initial bone loss, and soft-tissue outcomes improved suggesting favorable tissue response using anodized tapered conical connection implants. CLINICAL RELEVANCE: Rapid stabilization of bone remodeling and robust papilla regeneration indicate favorable tissue healing promoted by the conical connection, platform-shift design. TRIAL REGISTRATION: clinicaltrials.gov NCT02175550.
Assuntos
Remodelação Óssea/fisiologia , Coroas , Implantes Dentários para Um Único Dente , Prótese Dentária Fixada por Implante , Adolescente , Adulto , Idoso , Planejamento de Prótese Dentária , Estética Dentária , Feminino , Humanos , Carga Imediata em Implante Dentário , Tábuas de Vida , Masculino , Maxila/cirurgia , Pessoa de Meia-Idade , Satisfação do Paciente , Estudos Prospectivos , Resultado do TratamentoRESUMO
TNF-alpha is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-alpha in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-alpha is elevated in both cysts' fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-alpha was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p < 0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-alpha. We here for the first time present that a difference in the concentration of TNF-alpha exists between these two cystic types.
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Cistos Odontogênicos/química , Cisto Radicular/química , Fator de Necrose Tumoral alfa/análise , Líquido Cístico/química , HumanosRESUMO
TNF-α is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-α in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-α is elevated in both cysts' fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-α was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p<0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-α. We here for the first time present that a difference in the concentration of TNF-α exists between these two cystic types.
RESUMO
BACKGROUND/AIM: Surgical treatment of odontogenic cysts in childhood could be accompanied by injury of important anatomical structures. Even though enucleation is considered to be preferable treatment of odontogenic cysts, the specificities of pediatric age favor more conservative surgical approach. The aim of this study was to assess the effectiveness of decompression as the uttermost treatment of odontogenic cysts in the pediatric age. METHODS: This retrospective study included 22 patients, 7-16 years old, with a single jaw cystic lesion. The majority of these lesions were dentigerous cyst (14), and the rest belonged to keratocystic odontogenic tumor (KCOT) (8). All lesions were primarily treated with decompression; it was a final treatment (one-stage procedure) in 13 dentigerous cysts, and it was followed by enucleation (two-stage procedure) in one dentigerous cyst and all the KCOT. RESULTS: A total of 13 (59.1%) dentigerous cysts were treated successfully only with decompression as one stage procedure, while the other 9 (40.9%) cysts required enucleation (1 dentigerous and 8 KCOT), after decompression (p ≤ 0.001). CONCLUSION: Related to non-aggressive lesions, more conservative treatment approach, such as decompression as one-stage procedure, should be considered. On the other hand, KCOTs in children require a two-stage procedure for a successful treatment outcome.
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Regeneração Óssea , Descompressão Cirúrgica/métodos , Cistos Odontogênicos , Adolescente , Criança , Feminino , Humanos , Masculino , Cistos Odontogênicos/diagnóstico por imagem , Cistos Odontogênicos/fisiopatologia , Cistos Odontogênicos/cirurgia , Período Pós-Operatório , Radiografia Panorâmica/métodos , Estudos Retrospectivos , SérviaRESUMO
PURPOSES: The primary aim of the study was to investigate a 1-year success rate of early-loaded bone level implants with a chemically modified sand-blasted, large grit, acid-etched surface (SLActive®, Institut Straumann AG, Basel, Switzerland) in the posterior maxilla. Secondary objectives included stability of these implants and peri-implant bone level. MATERIALS AND METHODS: Bone level® implants (Institut Straumann AG) inserted into premolar and/or molar maxillary sites were loaded after 6 weeks of healing. The implants were monitored for 1 year using the following outcome measures: implant success, primary and secondary stability, and peri-implant bone level. RESULTS: Out of 37 implants placed in 13 patients, 36 reached sufficient stability and were early loaded, whereas one underwent a delayed loading protocol. One-year success rate of early-loaded implants was 100%. Implant stability at baseline was 71.7 ± 5. 6 to be steadily increased thereafter up to 1 year (80.3 ± 3.3), except at 2 weeks when a nonsignificant decrease was noticed (71.9 ± 3.9). Continuous and significant bone loss was observed, reaching 0.4 ± 0.1 mm in the first postoperative year. CONCLUSION: Bone level implants with the SLActive surface placed into low-density bone and loaded after 6 weeks of healing can predictably achieve and maintain a successful tissue integration.
Assuntos
Implantação Dentária Endóssea/métodos , Implantes Dentários , Maxila/cirurgia , Osseointegração , Adulto , Prótese Dentária , Feminino , Humanos , Masculino , Maxila/diagnóstico por imagem , Pessoa de Meia-Idade , Estudos Prospectivos , Radiografia DentáriaRESUMO
PURPOSE: The aim of this study was to investigate the relationship between surgical techniques and implant macro-design (self-tapping/non-self-tapping) for the optimization of implant stability in the low-density bone present in the posterior maxilla using resonance frequency analysis (RFA). MATERIALS AND METHODS: A total of 102 implants were studied. Fifty-six self-tapping BlueSkyBredent® (Bredent GmbH&Co.Kg®, Senden, Germany) and 56 non-self-tapping Standard Plus Straumann® (Institut Straumann AG®, Waldenburg, Switzerland) were placed in the posterior segment of the maxilla. Implants of both types were placed in sites prepared with either lateral bone-condensing or with bone-drilling techniques. Implant stability measurements were performed using RFA immediately after implant placement and weekly during a 12-week follow-up period. RESULTS: Both types of implants placed after bone condensing achieved significantly higher stability immediately after surgery, as well as during the entire 12-week observation period compared with those placed following bone drilling. After bone condensation, there were no significant differences in primary stability or in implant stability after the first week between both implant types. From 2 to 12 postoperative weeks, significantly higher stability was shown by self-tapping implants. After bone drilling, self-tapping implants achieved significantly higher stability than non-self-tapping implants during the entire follow-up period. CONCLUSIONS: The outcomes of the present study indicate that bone drilling is not an effective technique for improving implant stability and, following this technique, the use of self-tapping implants is highly recommended. Implant stability optimization in the soft bone can be achieved by lateral bone-condensing technique, regardless of implant macro-design.
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Implantes Dentários , Planejamento de Prótese Dentária , Retenção em Prótese Dentária , Adulto , Densidade Óssea/fisiologia , Tomografia Computadorizada de Feixe Cônico/métodos , Implantação Dentária Endóssea/instrumentação , Implantação Dentária Endóssea/métodos , Feminino , Seguimentos , Humanos , Masculino , Maxila/cirurgia , Osteotomia/instrumentação , Osteotomia/métodos , Planejamento de Assistência ao Paciente , VibraçãoRESUMO
OBJECTIVE: The aim of this clinical trial was to compare primary and secondary stability of implants placed by bone condensing versus the standard drilling technique in the posterior edentulous maxilla. STUDY DESIGN: Forty-eight SLA Straumann implants 4.1 × 10 mm (Institut Straumann AG, Waldenburg, Switzerland) were placed into edentulous maxillary posterior region in the same positions bilaterally, using the bone condensation technique for one and the standard technique for the other side. Implant stability measurements were performed immediately after implant placement, as well as every week for the next 6 weeks by use of resonance frequency analysis (RFA). Data were analyzed using Mann-Whitney U and Wilcoxon tests. RESULTS: After bone condensing, significantly higher implant stability was recorded immediately after surgery as well as during the whole observation period of 6 weeks compared with bone-drilling technique (Mann-Whitney U test, P = .000). CONCLUSIONS: The bone-condensing technique can be recommended as an alternate surgical approach for implant site preparation in reduced bone density to achieve greater implant stability in the posterior maxilla.
Assuntos
Densidade Óssea , Implantação Dentária Endóssea/instrumentação , Arcada Edêntula/cirurgia , Maxila/cirurgia , Procedimentos Cirúrgicos Pré-Protéticos Bucais/instrumentação , Processo Alveolar/diagnóstico por imagem , Processo Alveolar/cirurgia , Implantação Dentária Endóssea/métodos , Retenção em Prótese Dentária , Falha de Restauração Dentária , Feminino , Seguimentos , Humanos , Arcada Edêntula/diagnóstico por imagem , Masculino , Maxila/diagnóstico por imagem , Procedimentos Cirúrgicos Pré-Protéticos Bucais/métodos , Osseointegração , Radiografia , Estatísticas não Paramétricas , Resultado do TratamentoRESUMO
OBJECTIVE: The aim of this study was to compare changes in temperature of the surrounding bone at various osteotomy depths during implant site preparation by bone condensing and by bone drilling as well as the dynamics of their change. STUDY DESIGN: In the present "in vitro" study, pig ribs with uniform thickness of cortical bone of 2 mm were used. Lateral bone-condensing (experimental group) and bone-drilling techniques (control group) were performed. Temperature changes were recorded at a distance of 0.5 mm from the final test osteotomy by 3 thermocouples at the depths of 1, 5, and 10 mm in tripod configuration. Data were collected from 48 measurements, 24 for each group. RESULTS: Significantly higher mean temperature increase at the depth of 5 mm was observed during bone drilling compared with bone condensing, whereas for the depths of 1 and 10 mm differences were not significant between the 2 surgical techniques. During bone condensing, the mean temperature rise was continuously decreasing with increasing depth of osteotomies, whereas during bone drilling the mean temperature rise was first increased and reached a peak at the depth of 5 mm and then began to decrease with increasing depth of the osteotomies. CONCLUSIONS: The bone-condensing technique applied in the jaw bone class D4 offers an advantage over bone drilling because it generates a significantly smaller amount of heat.
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Temperatura Corporal/fisiologia , Densidade Óssea/fisiologia , Osteotomia/métodos , Costelas/cirurgia , Animais , Masculino , Osteotomia/instrumentação , Distribuição Aleatória , Costelas/patologia , Suínos , TermômetrosRESUMO
PURPOSE: This study was intended to investigate, through resonance frequency analysis (RFA), the stability of implants placed in an early loading protocol via the osteotome sinus floor elevation technique in the posterior maxilla. All implants featured a sandblasted/acid-etched active surface. MATERIALS AND METHODS: An early loading protocol was considered for patients in whom implants with a sandblasted, large-grit/acid-etched active surface (SLActive) were placed in the posterior maxilla by the osteotome sinus floor elevation technique. Implant stability, which was measured by RFA at surgery and at weekly intervals for the following 6 weeks, was used as the most significant inclusion criterion. At the end of the stability observation period, only implants with a stability quotient of 65 or higher were loaded. Implants were followed for 2 years. RESULTS: Twenty-seven patients received 42 implants, 40 of which were subjected to an early loading protocol 6 weeks after placement. Two years after loading, all 40 implants were surviving, without clinically or radiographically detectible complications. CONCLUSION: An early loading protocol can be used for SLActive implants placed in the posterior maxilla via the osteotome sinus floor elevation technique if their stability is confirmed by RFA.
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Implantação Dentária Endóssea/métodos , Implantes Dentários , Retenção em Prótese Dentária , Carga Imediata em Implante Dentário , Levantamento do Assoalho do Seio Maxilar/métodos , Adulto , Dente Pré-Molar , Coroas , Corrosão Dentária , Prótese Parcial Fixa , Feminino , Humanos , Masculino , Maxila/cirurgia , Pessoa de Meia-Idade , Dente Molar , Osseointegração , Osteotomia/instrumentação , Estudos Retrospectivos , Propriedades de Superfície , Vibração , Adulto JovemRESUMO
BACKGROUND: Maxillary tuberosity during teeth extraction can occur in dental practice. The aim of this paper was to present a case of the maxillary tuberosity fracture occurred during tooth extraction, which was the subject of the forensic expertise. CASE REPORT: The maxillary tuberosity fracture created during the extraction of the upper molar was neither timely nor adequately managed by the doctor who started extraction. After the treatment at the specialist institution, the patient sued the doctor for the criminal offense of negligent treatment. The task of the expert was to give a professional answer to the question whether the doctor, who caused a maxillary tuberosity fracture during the tooth extraction, acted negligently and applied inadequate treatment. CONCLUSION: The maxillary tuberosity fracture during molar extraction may be its complication. If it is diagnosed promptly, immediately and adequately managed, there is no possibility for negligence action.