Pesquisa | Secretaria de Estado da Saúde

1.

Biomaterial and cellular implants: foreign surfaces where immunity and coagulation meet.

Kizhakkedathu, Jayachandran N; Conway, Edward M.

Blood ; 139(13): 1987-1998, 2022 03 31.

Artigo Inglês | MEDLINE | ID: mdl-34415324

2.

Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest.

Hoiland, Ryan L; Ainslie, Philip N; Wellington, Cheryl L; Cooper, Jennifer; Stukas, Sophie; Thiara, Sonny; Foster, Denise; Fergusson, Nicholas A; Conway, Edward M; Menon, David K; Gooderham, Peter; Hirsch-Reinshagen, Veronica; Griesdale, Donald E; Sekhon, Mypinder S.

Circ Res ; 129(5): 583-597, 2021 08 20.

Artigo Inglês | MEDLINE | ID: mdl-34287000

3.

Chondrocyte Thrombomodulin Protects against Osteoarthritis.

Kang, Lin; Yang, Ai-Lun; Lai, Chao-Han; Chen, Tsan-Ju; Lin, Sung-Yen; Wang, Yan-Hsiung; Wang, Chau-Zen; Conway, Edward M; Wu, Hua-Lin; Ho, Mei-Ling; Chang, Je-Ken; Chen, Chung-Hwan; Cheng, Tsung-Lin.

Int J Mol Sci ; 24(11)2023 May 30.

Artigo Inglês | MEDLINE | ID: mdl-37298473

4.

Complement contributions to COVID-19.

Conway, Edward M; Pryzdial, Edward L G.

Curr Opin Hematol ; 29(5): 259-265, 2022 09 01.

Artigo Inglês | MEDLINE | ID: mdl-35852851

5.

Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses.

Tsai, Meng-Shan; Wang, Li-Chiu; Wu, Hua-Lin; Tzeng, Shun-Fen; Conway, Edward M; Hsu, Sheng-Min; Chen, Shun-Hua.

J Neuroinflammation ; 19(1): 66, 2022 Mar 11.

Artigo Inglês | MEDLINE | ID: mdl-35277184

6.

Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.

Strilchuk, Amy W; Meixner, Scott C; Leung, Jerry; Safikhan, Nooshin S; Kulkarni, Jayesh A; Russell, Hannah M; van der Meel, Roy; Sutherland, Michael R; Owens, A Phillip; Palumbo, Joseph S; Conway, Edward M; Pryzdial, Edward L G; Cullis, Pieter R; Kastrup, Christian J.

Blood ; 136(25): 2946-2954, 2020 12 17.

Artigo Inglês | MEDLINE | ID: mdl-32678423

7.

An improved in vitro model for studying the structural and functional properties of the endothelial glycocalyx in arteries, capillaries and veins.

Siren, Erika M J; Luo, Haiming D; Bajaj, Sargun; MacKenzie, Jordan; Daneshi, Masoud; Martinez, D Mark; Conway, Edward M; Cheung, Karen C; Kizhakkedathu, Jayachandran N.

FASEB J ; 35(6): e21643, 2021 06.

Artigo Inglês | MEDLINE | ID: mdl-33977574

8.

Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortality.

Leatherdale, Alexander; Stukas, Sophie; Lei, Victor; West, Henry E; Campbell, Christopher J; Hoiland, Ryan L; Cooper, Jennifer; Wellington, Cheryl L; Sekhon, Mypinder S; Pryzdial, Edward L G; Conway, Edward M.

Med Microbiol Immunol ; 211(1): 37-48, 2022 Feb.

Artigo Inglês | MEDLINE | ID: mdl-35034207

9.

VEGF-Induced Endothelial Podosomes via ROCK2-Dependent Thrombomodulin Expression Initiate Sprouting Angiogenesis.

Kuo, Cheng-Hsiang; Huang, Yi-Hsun; Chen, Po-Ku; Lee, Gang-Hui; Tang, Ming-Jer; Conway, Edward M; Shi, Guey-Yueh; Wu, Hua-Lin.

Arterioscler Thromb Vasc Biol ; 41(5): 1657-1671, 2021 05 05.

Artigo Inglês | MEDLINE | ID: mdl-33730876

10.

Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway.

Huang, Yi-Hsun; Kuo, Cheng-Hsiang; Peng, I-Chen; Chang, Yi-Sheng; Tseng, Sung-Huei; Conway, Edward M; Wu, Hua-Lin.

Cell Mol Life Sci ; 78(23): 7681-7692, 2021 Dec.

Artigo Inglês | MEDLINE | ID: mdl-34705054

11.

Releasates of riboflavin/UV-treated platelets: Microvesicles suppress cytokine-mediated endothelial cell migration/proliferation.

Schubert, Peter; Culibrk, Luka; Culibrk, Brankica; Conway, Edward M; Goodrich, Raymond P; Devine, Dana V.

Transfusion ; 61(5): 1551-1561, 2021 05.

Artigo Inglês | MEDLINE | ID: mdl-33629371

12.

Exploring traditional and nontraditional roles for thrombomodulin.

Loghmani, Houra; Conway, Edward M.

Blood ; 132(2): 148-158, 2018 07 12.

Artigo Inglês | MEDLINE | ID: mdl-29866818

13.

Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA.

Kalathottukaren, Manu Thomas; Abraham, Libin; Kapopara, Piyushkumar R; Lai, Benjamin F L; Shenoi, Rajesh A; Rosell, Federico I; Conway, Edward M; Pryzdial, Edward L G; Morrissey, James H; Haynes, Charles A; Kizhakkedathu, Jayachandran N.

Blood ; 129(10): 1368-1379, 2017 03 09.

Artigo Inglês | MEDLINE | ID: mdl-28034889

14.

The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech.

Pang, Siew Siew; Wijeyewickrema, Lakshmi C; Hor, Lilian; Tan, Sheareen; Lameignere, Emilie; Conway, Edward M; Blom, Anna M; Mohlin, Frida C; Liu, Xuyu; Payne, Richard J; Whisstock, James C; Pike, Robert N.

J Immunol ; 199(11): 3883-3891, 2017 12 01.

Artigo Inglês | MEDLINE | ID: mdl-29061764

15.

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Wijeyewickrema, Lakshmi C; Lameignere, Emilie; Hor, Lilian; Duncan, Renee C; Shiba, Toshikazu; Travers, Richard J; Kapopara, Piyushkumar R; Lei, Victor; Smith, Stephanie A; Kim, Hugh; Morrissey, James H; Pike, Robert N; Conway, Edward M.

Blood ; 128(13): 1766-76, 2016 09 29.

Artigo Inglês | MEDLINE | ID: mdl-27338096

16.

Cross Talk Pathways Between Coagulation and Inflammation.

Foley, Jonathan H; Conway, Edward M.

Circ Res ; 118(9): 1392-408, 2016 Apr 29.

Artigo Inglês | MEDLINE | ID: mdl-27126649

17.

Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells.

Miletic, Ana V; Jellusova, Julia; Cato, Matthew H; Lee, Charlotte R; Baracho, Gisele V; Conway, Edward M; Rickert, Robert C.

J Immunol ; 196(5): 2195-204, 2016 Mar 01.

Artigo Inglês | MEDLINE | ID: mdl-26810226

18.

Hepatocellular carcinoma repression by TNFα-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization.

Li, Dan; Fu, Jing; Du, Min; Zhang, Haibin; Li, Lu; Cen, Jin; Li, Weiyun; Chen, Xiaotao; Lin, Yunfei; Conway, Edward M; Pikarsky, Eli; Wang, Hongyan; Pan, Guoyu; Ji, Yuan; Wang, Hong-Yang; Hui, Lijian.

Hepatology ; 64(4): 1105-20, 2016 10.

Artigo Inglês | MEDLINE | ID: mdl-27177758

19.

HUS and the case for complement.

Conway, Edward M.

Blood ; 126(18): 2085-90, 2015 Oct 29.

Artigo Inglês | MEDLINE | ID: mdl-26396094

20.

Polyphosphate suppresses complement via the terminal pathway.

Wat, Jovian M; Foley, Jonathan H; Krisinger, Michael J; Ocariza, Linnette Mae; Lei, Victor; Wasney, Gregory A; Lameignere, Emilie; Strynadka, Natalie C; Smith, Stephanie A; Morrissey, James H; Conway, Edward M.

Blood ; 123(5): 768-76, 2014 Jan 30.

Artigo Inglês | MEDLINE | ID: mdl-24335501

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