Detalhe da pesquisa
1.
Structure-specific roles for PolG2-DNA complexes in maintenance and replication of mitochondrial DNA.
Nucleic Acids Res
; 51(18): 9716-9732, 2023 Oct 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37592734
2.
Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Proc Natl Acad Sci U S A
; 119(32): e2207459119, 2022 08 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35914129
3.
Activation of the SARS-CoV-2 NSP14 3'-5' exoribonuclease by NSP10 and response to antiviral inhibitors.
J Biol Chem
; 298(1): 101518, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34942146
4.
Method for the structural analysis of Twinkle mitochondrial DNA helicase by cryo-EM.
Methods
; 205: 263-270, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35779765
5.
Polymerase γ efficiently replicates through many natural template barriers but stalls at the HSP1 quadruplex.
J Biol Chem
; 295(51): 17802-17815, 2020 12 18.
Artigo
Inglês
| MEDLINE | ID: mdl-33454015
6.
Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase.
J Biol Chem
; 295(17): 5564-5576, 2020 04 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32213598
7.
Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein.
Nucleic Acids Res
; 46(21): 11287-11302, 2018 11 30.
Artigo
Inglês
| MEDLINE | ID: mdl-30256971
8.
Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.
Nucleic Acids Res
; 45(17): 10079-10088, 2017 Sep 29.
Artigo
Inglês
| MEDLINE | ID: mdl-28973450
9.
Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations.
J Biol Chem
; 292(10): 4198-4209, 2017 03 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28154168
10.
DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides.
Nucleic Acids Res
; 44(19): 9381-9392, 2016 Nov 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27591252
11.
POLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity.
Hum Mol Genet
; 24(18): 5184-97, 2015 Sep 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26123486
12.
MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants.
PLoS Genet
; 10(10): e1004748, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25340760
13.
DNA2 resolves expanding flap in mitochondrial base excision repair.
Mol Cell
; 32(4): 457-8, 2008 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-19026774
14.
Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.
Hum Mol Genet
; 22(6): 1074-85, 2013 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23208208
15.
Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance.
Hum Mol Genet
; 22(5): 1017-25, 2013 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23197651
16.
Mitochondrial Disease Sequence Data Resource (MSeqDR): a global grass-roots consortium to facilitate deposition, curation, annotation, and integrated analysis of genomic data for the mitochondrial disease clinical and research communities.
Mol Genet Metab
; 114(3): 388-96, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25542617
17.
Defects in mitochondrial DNA replication and human disease.
Crit Rev Biochem Mol Biol
; 47(1): 64-74, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22176657
18.
Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γ.
J Biol Chem
; 288(20): 14247-14255, 2013 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-23543747
19.
Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers.
J Biol Chem
; 287(12): 9222-9, 2012 Mar 16.
Artigo
Inglês
| MEDLINE | ID: mdl-22194617
20.
The interface of transcription and DNA replication in the mitochondria.
Biochim Biophys Acta
; 1819(9-10): 970-8, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22207204