Detalhe da pesquisa
1.
Early use of nitazoxanide in mild COVID-19 disease: randomised, placebo-controlled trial.
Eur Respir J
; 58(1)2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33361100
2.
Discovery of antichagasic inhibitors by high-throughput screening with Trypanosoma cruzi glucokinase.
Bioorg Med Chem Lett
; 29(15): 1948-1953, 2019 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31133533
3.
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds.
Virulence
; 13(1): 1031-1048, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35734825
4.
Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box.
ACS Infect Dis
; 7(8): 2455-2471, 2021 08 13.
Artigo
Inglês
| MEDLINE | ID: mdl-34279922
5.
High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules.
ACS Pharmacol Transl Sci
; 4(6): 1849-1866, 2021 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34927015
6.
16-bromoepiandrosterone, an activator of the mammalian immune system, inhibits glucose 6-phosphate dehydrogenase from Trypanosoma cruzi and is toxic to these parasites grown in culture.
Bioorg Med Chem
; 18(13): 4762-8, 2010 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20570159
7.
In Vitro Image-Based Assay for Trypanosoma cruzi Intracellular Forms.
Methods Mol Biol
; 2116: 773-780, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32221954
8.
Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa.
Commun Biol
; 3(1): 263, 2020 05 25.
Artigo
Inglês
| MEDLINE | ID: mdl-32451394
9.
Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites.
Bioorg Med Chem
; 17(6): 2483-9, 2009 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19231202
10.
NADPH Producing Enzymes as Promising Drug Targets for Chagas Disease.
Curr Med Chem
; 26(36): 6564-6571, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30306853
11.
Synthesis and testing of novel alternative oxidase (AOX) inhibitors with antifungal activity against Moniliophthora perniciosa (Stahel), the causal agent of witches' broom disease of cocoa, and other phytopathogens.
Pest Manag Sci
; 75(5): 1295-1303, 2019 May.
Artigo
Inglês
| MEDLINE | ID: mdl-30350447
12.
The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes.
J Mol Biol
; 372(5): 1215-26, 2007 Oct 05.
Artigo
Inglês
| MEDLINE | ID: mdl-17761195
13.
First Nonphosphorylated Inhibitors of Phosphoglucose Isomerase Identified by Chemical Library Screening.
SLAS Discov
; 23(10): 1051-1059, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29995453
14.
Identification of Specific Inhibitors of Trypanosoma cruzi Malic Enzyme Isoforms by Target-Based HTS.
SLAS Discov
; 22(9): 1150-1161, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28459632
15.
Crystallization and preliminary X-ray diffraction analysis of Leishmania major dihydroorotate dehydrogenase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 10): 1049-51, 2006 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-17012810
16.
The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme.
FEBS Lett
; 590(16): 2776-86, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27391210
17.
Discovery of new uncompetitive inhibitors of glucose-6-phosphate dehydrogenase.
J Biomol Screen
; 19(10): 1362-71, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25121555
18.
Crystal structure of dihydroorotate dehydrogenase from Leishmania major.
Biochimie
; 94(8): 1739-48, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22542640
19.
Structural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase.
FEBS J
; 279(11): 2012-21, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22458781
20.
Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids.
Mol Biochem Parasitol
; 176(2): 112-5, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21185333