Detalhe da pesquisa
1.
CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
Mol Microbiol
; 101(3): 381-93, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27073104
2.
Identification of pathogen genomic variants through an integrated pipeline.
BMC Bioinformatics
; 15: 63, 2014 Mar 03.
Artigo
Inglês
| MEDLINE | ID: mdl-24589256
3.
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Science
; 359(6372): 191-199, 2018 01 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29326268
4.
Esterase mutation is a mechanism of resistance to antimalarial compounds.
Nat Commun
; 8: 14240, 2017 01 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28106035
5.
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.
Nat Microbiol
; 2(10): 1403-1414, 2017 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-28808258
6.
Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.
ACS Infect Dis
; 2(11): 816-826, 2016 11 11.
Artigo
Inglês
| MEDLINE | ID: mdl-27933786
7.
Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation.
Am J Trop Med Hyg
; 94(2): 302-313, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26711524
8.
A broad analysis of resistance development in the malaria parasite.
Nat Commun
; 7: 11901, 2016 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27301419
9.
Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes.
ACS Infect Dis
; 1(8): 367-79, 2015 Aug 14.
Artigo
Inglês
| MEDLINE | ID: mdl-26719854