EXP-Crowd: A Gamified Crowdsourcing Framework for Explainability.

The spread of AI and black-box machine learning models made it necessary to explain their behavior. Consequently, the research field of Explainable AI was born. The main objective of an Explainable AI system is to be understood by a human as the final beneficiary of the model. In our research, we frame the explainability problem from the crowds point of view and engage both users and AI researchers through a gamified crowdsourcing framework. We research whether it's possible to improve the crowds understanding of black-box models and the quality of the crowdsourced content by engaging users in a set of gamified activities through a gamified crowdsourcing framework named EXP-Crowd. While users engage in such activities, AI researchers organize and share AI- and explainability-related knowledge to educate users. We present the preliminary design of a game with a purpose (G.W.A.P.) to collect features describing real-world entities which can be used for explainability purposes. Future works will concretise and improve the current design of the framework to cover specific explainability-related needs.

Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2.

The sleep disorder narcolepsy is linked to the HLA-DQB1*0602 haplotype and dysregulation of the hypocretin ligand-hypocretin receptor pathway. Narcolepsy was associated with Pandemrix vaccination (an adjuvanted, influenza pandemic vaccine) and also with infection by influenza virus during the 2009 A(H1N1) influenza pandemic. In contrast, very few cases were reported after Focetria vaccination (a differently manufactured adjuvanted influenza pandemic vaccine). We hypothesized that differences between these vaccines (which are derived from inactivated influenza viral proteins) explain the association of narcolepsy with Pandemrix-vaccinated subjects. A mimic peptide was identified from a surface-exposed region of influenza nucleoprotein A that shared protein residues in common with a fragment of the first extracellular domain of hypocretin receptor 2. A significant proportion of sera from HLA-DQB1*0602 haplotype-positive narcoleptic Finnish patients with a history of Pandemrix vaccination (vaccine-associated narcolepsy) contained antibodies to hypocretin receptor 2 compared to sera from nonnarcoleptic individuals with either 2009 A(H1N1) pandemic influenza infection or history of Focetria vaccination. Antibodies from vaccine-associated narcolepsy sera cross-reacted with both influenza nucleoprotein and hypocretin receptor 2, which was demonstrated by competitive binding using 21-mer peptide (containing the identified nucleoprotein mimic) and 55-mer recombinant peptide (first extracellular domain of hypocretin receptor 2) on cell lines expressing human hypocretin receptor 2. Mass spectrometry indicated that relative to Pandemrix, Focetria contained 72.7% less influenza nucleoprotein. In accord, no durable antibody responses to nucleoprotein were detected in sera from Focetria-vaccinated nonnarcoleptic subjects. Thus, differences in vaccine nucleoprotein content and respective immune response may explain the narcolepsy association with Pandemrix.