Detalhe da pesquisa
1.
The SMAC mimetic GDC-0152 is a direct ABCB1-ATPase activity modulator and BIRC5 expression suppressor in cancer cells.
Toxicol Appl Pharmacol
; 485: 116888, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38452945
2.
Functional inhibition of c-Myc using novel inhibitors identified through "hot spot" targeting.
J Biol Chem
; 298(5): 101898, 2022 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35378126
3.
Synthesis, antitubercular evaluation, and molecular docking studies of hybrid pyridinium salts derived from isoniazid.
Drug Dev Res
; 84(3): 470-483, 2023 05.
Artigo
Inglês
| MEDLINE | ID: mdl-36744647
4.
The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells.
Toxicol Appl Pharmacol
; 401: 115080, 2020 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32497533
5.
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.
Bioorg Chem
; 98: 103689, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32171993
6.
Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli.
Protein Expr Purif
; 160: 73-83, 2019 08.
Artigo
Inglês
| MEDLINE | ID: mdl-31004782
7.
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
Proc Natl Acad Sci U S A
; 110(19): E1779-87, 2013 May 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23610398
8.
Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.
J Comput Aided Mol Des
; 29(1): 89-100, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25344840
9.
Deciphering Breast Cancer Metastasis Cascade: A Systems Biology Approach Integrating Transcriptome and Interactome Insights for Target Discovery.
OMICS
; 28(3): 148-161, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38484298
10.
Exploring imidazo[4,5-g]quinoline-4,9-dione derivatives as Acinetobacter baumannii efflux pump inhibitor: an in silico approach.
J Biomol Struct Dyn
; : 1-20, 2023 Nov 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37937796
11.
Targeting survivin for cancer therapy: Strategies, small molecule inhibitors and vaccine based therapeutics in development.
Life Sci
; 335: 122260, 2023 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37963509
12.
Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
J Med Chem
; 66(4): 2566-2588, 2023 02 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36749735
13.
Pan-cancer gene expression analysis: Identification of deregulated autophagy genes and drugs to target them.
Gene
; 844: 146821, 2022 Nov 30.
Artigo
Inglês
| MEDLINE | ID: mdl-35985410
14.
Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting.
Tissue Barriers
; 10(4): 2013695, 2022 10 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34957912
15.
Deciphering molecular mechanisms of metastasis: novel insights into targets and therapeutics.
Cell Oncol (Dordr)
; 44(4): 751-775, 2021 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-33914273
16.
Investigation of Alpinia calcarata constituent interactions with molecular targets of rheumatoid arthritis: docking, molecular dynamics, and network approach.
J Mol Model
; 27(1): 14, 2021 Jan 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33403456
17.
Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design.
ACS Omega
; 6(9): 6100-6111, 2021 Mar 09.
Artigo
Inglês
| MEDLINE | ID: mdl-33718701
18.
Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia.
Pharmacol Rep
; 73(2): 615-628, 2021 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-33389727
19.
The ribosomal protein eL21 interacts with the protein lysine methyltransferase SMYD2 and regulates its steady state levels.
Biochim Biophys Acta Mol Cell Res
; 1868(9): 119079, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-34147559
20.
Overcoming vincristine resistance in cancer: Computational design and discovery of piperine-inspired P-glycoprotein inhibitors.
Chem Biol Drug Des
; 97(1): 51-66, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32633857