Detalhe da pesquisa
1.
INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.
Genes Dev
; 30(12): 1440-53, 2016 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27340176
2.
Scenarios of maternal mortality reduction by 2030 in the Americas: insights from its tempo.
Int J Equity Health
; 22(1): 121, 2023 06 28.
Artigo
Inglês
| MEDLINE | ID: mdl-37381010
3.
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer.
J Biol Chem
; 297(5): 101335, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34688654
4.
Data gaps towards health development goals, 47 low- and middle-income countries.
Bull World Health Organ
; 100(1): 40-49, 2022 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35017756
5.
The role of wild type RAS isoforms in cancer.
Semin Cell Dev Biol
; 58: 60-9, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27422332
6.
K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.
Proc Natl Acad Sci U S A
; 112(3): 779-84, 2015 Jan 20.
Artigo
Inglês
| MEDLINE | ID: mdl-25561545
7.
Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma.
J Biol Chem
; 291(34): 17804-15, 2016 08 19.
Artigo
Inglês
| MEDLINE | ID: mdl-27226552
8.
Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.
J Biol Chem
; 290(37): 22851-61, 2015 Sep 11.
Artigo
Inglês
| MEDLINE | ID: mdl-26216878
9.
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.
Cancer Cell
; 12(5): 467-78, 2007 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-17996650
10.
Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration.
J Biol Chem
; 288(46): 33156-70, 2013 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24089523
11.
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer.
Science
; 384(6700): eadk0850, 2024 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-38843329
12.
Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers.
Science
; 384(6700): eadk0775, 2024 Jun 07.
Artigo
Inglês
| MEDLINE | ID: mdl-38843331
13.
Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.
J Biol Chem
; 287(18): 14827-36, 2012 Apr 27.
Artigo
Inglês
| MEDLINE | ID: mdl-22393054
14.
Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
Cancer Cell
; 7(6): 533-45, 2005 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-15950903
15.
Convergence of Targeted and Immune Therapies for the Treatment of Oncogene-Driven Cancers.
Cancer Discov
; 13(1): 19-22, 2023 01 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36620884
16.
VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS-mutant pancreatic cancer.
Genes Cancer
; 14: 30-49, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36923647
17.
TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors.
Cancer Res
; 83(24): 4112-4129, 2023 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37934103
18.
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer.
Cancer Res
; 83(1): 141-157, 2023 01 04.
Artigo
Inglês
| MEDLINE | ID: mdl-36346366
19.
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
Sci Signal
; 16(816): eadg5289, 2023 12 19.
Artigo
Inglês
| MEDLINE | ID: mdl-38113333
20.
Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer.
Adv Cancer Res
; 153: 101-130, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35101228