Biological basis of child health 15: understanding the renal system and common renal conditions in children.

This article, the 15th and last in a series on the biological basis of child health, focuses on the renal system, in particular the kidneys. It provides an overview of their role, function, anatomy and physiology, and embryological development. The renal system has a crucial role in homeostasis, so renal function impairment can have wide-ranging and potentially serious consequences for a child's overall health. The article describes some of the common renal conditions seen in children and how these are managed. It explains how to interpret the results of renal function tests and urine sampling conducted to assess renal function and to investigate acute and chronic disease.

Biological basis of child health 10: function and formation of blood and common blood disorders in children.

This article, the tenth in a series on the biological basis of child health, focuses on blood. Blood has a crucial role in the transport of substances such as respiratory gases, nutrients and antibodies, as well as in acid-base balance, fluid balance, blood clotting and the immune system. This article describes the composition, formation and function of blood, outlines normal blood count values and explains the effects of low blood cell counts in children. It also provides an overview of the blood disorders that are commonly seen in children, including anaemia, sickle cell disease, clotting disorders and blood cancers. It is essential for children's nurses to have knowledge and an understanding of blood, including its physiology and pathophysiology, to provide optimal care and support to children and young people and their families.

Biological basis of child health 14: understanding the immune system, vaccines, allergy and disease.

This article, the 14th in a series on the biological basis of child health, focuses on the immune system. It provides an overview of pathogens to which the human body is susceptible, some of the milestones in the embryological development of the immune system, and some of the mechanisms of innate and acquired immunity. The article explains the importance of immunisations and provides examples of immune system dysfunctions and autoimmune conditions that children may experience. It is essential that children's nurses have an understanding of how the immune system develops, how it is structured and how it functions, since such knowledge will be relevant in the care of a range of conditions where nurses need to explain infection, inflammation and immune processes to children and parents.

Biological basis of child health 6: development of the skeletal system and orthopaedic conditions.

This article is the sixth in a series on the biological basis of child health. It provides an overview of the development of the skeletal system before and after birth, and outlines the potential congenital anomalies that may occur. The article explains the structure and function of the bones before describing the role of the joints, tendons and ligaments. It also outlines the presentation and management of some of the common orthopaedic conditions seen in infants and children, including fractures, osteogenesis imperfecta, scoliosis, juvenile idiopathic arthritis, developmental dysplasia of the hip and achondroplasia.

Biological basis of child health 2: introduction to fertilisation, prenatal development and birth.

This article is the second in a series called the biological basis of child health. It considers the period of development from fertilisation to birth, outlining the three stages of prenatal development - the germinal, embryonic and fetal stages. The article details how tissues and organs typically develop at each stage, and explains how and when deviations in development and congenital anomalies are likely to occur. It also describes some of the common congenital anomalies, their potential effects and their detection before or after birth. Information is also provided about the delivery of full-term infants, including the stages of labour.

Biological basis of child health 3: development of the cardiovascular system and congenital heart defects.

This article is the third in a series on the biological basis of child health. It outlines how the cardiovascular system develops during gestation and how congenital heart defects (CHDs) may arise in the process. The article details the pathophysiology and treatment of some of the common CHDs, including patent ductus arteriosus, atrial septal defect, ventricular septal defect and transposition of the great arteries. It explains the possible causes of CHDs and explains how these defects are detected and diagnosed. The article also provides an overview of the initial management of acutely unwell infants and children who present with a CHD. The first two articles in the series looked at cells and genetics, and embryology.

Biological basis of child health 4: an overview of the central nervous system and principles of neurological assessment.

This article is the fourth in a series on the biological basis of child health. It explains the embryological development of the nervous system and describes some of the anatomical and physiological features of the central nervous system, which is comprised of the brain and spinal cord. It also outlines the principles of neurological assessment in infants and children, before detailing the presentation and management of three conditions that can affect the central nervous system in this patient population - seizures, meningitis and raised intracranial pressure.

Biological basis of child health 5: development of the respiratory system and elements of respiratory assessment.

This article is the fifth in a series on the biological basis of child health. It describes the development of the respiratory system, which starts relatively late in the embryo and continues after birth until the age of seven to eight years. It explains what the developing anatomy of the respiratory system in infants and children means in terms of the conditions that may occur and the precautions required when assessing them. The article provides an overview of the elements of respiratory assessment in infants and children and describes some respiratory conditions seen in these patient groups. It also discusses some of the changes in the care of children with respiratory conditions, which has increasingly moved from hospital into the community and become nurse-led, multidisciplinary and holistic.

Equipping children's nurses to de-escalate conflict and communicate challenging information.

This article considers some of the challenging situations that children's nurses may encounter when there are tensions and disagreements between the family of the child or young person in their care and the wider professional team. The focus is on disagreements about what some might consider futile critical care. It aims to equip children's nurses with strategies for dealing with conflict and tensions, and support them to be proactive in identifying situations that might need de-escalation. The options available to support the healthcare team and therefore avoid litigation are explored, while avenues of support available to nursing staff are considered. Suggestions and examples of effective and skilful communication with families receiving challenging news are provided. The legal position designed to safeguard children's nurses is reviewed and practical strategies are offered to support nurses to protect themselves from physical violence if the situation escalates.

Just because we can, should we? A discussion of treatment withdrawal.

Children's nurses are vocationally committed to promoting the health of children, relieving their suffering, enhancing their development, helping them to achieve a sense of worth and a confidence in their future. Supporting parents and medical colleagues while the decision is made to withdraw or withhold life-sustaining treatment is one of the most difficult aspects of children's nursing practice. Current guidelines support the withholding or withdrawing of life-sustaining treatment from children in brain death, permanent vegetative state, and no chance, no purpose or unbearable situations. Societal and professional attitudes to euthanasia and assisted suicide may be changing and this could lead to changes in legislation and guidelines. However, nurses must be clear about the differences: currently any measure, practice or treatment administered with the primary intention to cause death is not allowed. This is not the same as any measure, practice or treatment administered with the intent to relieve suffering and promote comfort, that can cause or hasten death.

Healthcare assistants in the children's intensive care unit.

Recruiting and retaining qualified nurses for children's intensive care units is becoming more difficult because of falling numbers of recruits into the child branch and inadequate educational planning and provision. Meeting the staffing challenge and maintaining the quality of children's intensive care services requires flexible and creative approaches, including considered evolution of the role of healthcare assistants. Evidence from adult services indicates that the addition of healthcare assistants to the intensive care team can benefit patient care. The evolution of the healthcare assistant role to support provision of safe, effective care in the children's intensive care setting requires a comprehensive strategy to ensure that appropriate education, training and supervision are in place. Career development pathways need to be in place and role accountability clearly defined at the different stages of the pathway. Experience in one unit in Glasgow suggests that healthcare assistants make a valuable contribution to the care of critically ill children and young people.

The theory-practice gap: ECMO research example.

AIM: The time taken for research findings to enter clinical practice can be very lengthy. A contributing factor is the time lag between the research literature identifying the issue, and medical and nursing texts discussing it. The example of ECMO (Extracorporeal Membrane Oxygenation) is used to examine this issue, specifically the extent to which relevant nursing journals and textbooks discuss the effects of ECMO on medication. METHOD: A systematic review of papers identifying the problem (pharmacokinetics in ECMO patients) and the dissemination of this to clinicians was undertaken. Publications used by those exploring the problem were most likely to be found in Medline, and those disseminating to nurses in CINAHL. Textbooks on neonatal nursing and paediatric intensive care with sections on ECMO were also explored. RESULTS: There are several studies that show drug delivery is altered in patients receiving ECMO, dating back to 1989. Only three papers likely to be accessed by clinicians were found to address the effect of ECMO on drug delivery. Two of the textbooks addressed these issues but it took eight years from the issue being first raised to any medical or nursing text discussing it. CONCLUSION: Nurses will most likely not be aware of the latest research in their area if they rely on textbooks. Advanced education that gives critical appraisal and literature-searching skills, such as found in master's courses, should help the clinical nurse employ evidence based practice.

Understanding fluid homoeostasis in infants and children: part 2.

Part two of this article focuses on the care and management of infants and children who are seriously ill and who have lost so much fluid that they have entered a state of shock. The pathophysiology of shock is reviewed and the types and stages of shock are considered. The challenges of identifying shock are explored and the management of fluid resuscitation with colloids rather than crystalloids is analysed. An overview of the complex management of a young person in shock is provided using a case history format. The article offers the opportunity to extend readers' knowledge of some of the special tests that may be required to support the diagnosis of shock and provides an overview of the expected results.

Understanding fluid homeostasis in infants and children: part 1.

Fluid requirements differ between infants and children. It is important for children's nurses to understand the principles of fluid mechanics and apply this understanding to ensure each child's state of hydration, and thereby preserve their safety and well-being. This two-part article aims to introduce the concept of fluid balance and electrolytes to children's nursing students, help them identify what is normal and what is not, and provide guidance on what actions should be taken when problems occur. It may also be useful for registered nurses to use for revalidation.

Student life - Giving the best start in life.

How many nurses on adult wards get to kick off a medicines round with a game of hide-and-seek in a play room?

Haemolytic uraemic syndrome.

Although haemolytic uraemic syndrome is rare, it is not uncommon. Here is an overview of the syndrome, with advice on signs and symptoms and how to care for children and young people.

Understanding the physiology of sleep and promoting effective routines with infants in hospital and at home.

Sleep is a biological necessity. Infants are unique individuals and what can be regarded as normal for one infant and his or her family may be considered a problem for another. Genetics, lifestyles, roles and responsibilities all influence sleep. This article explores the physiology of infant sleep and reviews how sleep is influenced by culture, events such as a hospital admission and parenting styles. It considers how the children's nurse can help and support a family who may feel that they have infant sleep-related issues. A good sleep pattern is essential for a child to succeed at school, reach their full potential and maintain their health and well-being.

When parents no longer trust the professionals.

Away from the media spotlight, nurses in neonatal and intensive care units across the UK continue to do their jobs. Difficult ethical cases in these units, such as the one at the centre of the High Court challenge by the parents of baby Charlie Gard (pictured), are more common than people might think.

Joubert syndrome.

Named after the French doctor who first described this rare neurological condition, Joubert syndrome is characterised by developmental delay, hypotonia, ataxia and oculomotor apraxia.

Fanconi anaemia.

Fanconi anaemia is a rare inherited genetic condition that can lead to aplastic anaemia and bone marrow failure. People with the condition have a predisposition to some cancers. The condition is named after Swiss paediatrician Guido Fanconi.