RESUMO
Angioedema due to C1--inhibitor deficiency may be hereditary (HAE) or acquired (AAE). AAE is a very rare condition, whose prevalence is possibly underestimated, as it is often unrecognized. AAE usually occurs after the fourth decade of life, and it is commonly associated to an underlying disease, mainly lymphoproliferative disorders. We report a 74-years old woman with recurrent episodes of angioedema involving upper airways in which diagnosis was obtained a long time after symptoms onset. A concomitant B cell leukaemia was also diagnosed This report stresses the importance of the recognition of AAE: a delayed diagnosis is indeed associated to the risk of severe life-threatening episodes, unresponsive to the usual therapy of common form of angioedema. AAE should be considered as a possible diagnosis in subjects with adult onset of angioedema: a careful clinical history is basic, since the clinical features and the time-course are often suggestive of the disease.
Assuntos
Angioedema/etiologia , Proteínas Inativadoras do Complemento 1/deficiência , Idoso , Feminino , HumanosRESUMO
Pulmonary and extrapulmonary tuberculosis is still encountered in clinical practice, sometimes in forms that are difficult to categorize nosographically. In this study, the therapeutic efficacy of the 6 main antitubercular drugs (rifampicin, streptomycin, isoniazide, ethambutol, kanamycin, para-aminosalicylic acid) in 20 patients with early TB of the lungs was assessed on the basis of antibiogram findings. Para-aminosalicylic acid was found to be the least effective; isoniazide, rifampicin and streptomycin were reasonably so; both kanamycin and ethambutol were extremely effective.
Assuntos
Antituberculosos/farmacologia , Mycobacterium tuberculosis/efeitos dos fármacos , Adulto , Idoso , Antituberculosos/uso terapêutico , Pré-Escolar , Avaliação Pré-Clínica de Medicamentos , Resistência Microbiana a Medicamentos , Feminino , Humanos , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/microbiologiaRESUMO
The clinical case of a 67-year-old woman admitted for abdominal pain whose interpretation created difficulties but which corresponded substantially to the pain encountered in intestinal occlusion associated with diabetes mellitus and increase in amylasemia is reported. After decrease, 48 hours after hospitalization, necropsy revealed extensive acute pancreatitis associated with infarction of the small bowel to occlusion of the superior mesenteric artery.
Assuntos
Obstrução Duodenal/complicações , Infarto/etiologia , Intestino Delgado/irrigação sanguínea , Pancreatite/etiologia , Síndrome da Artéria Mesentérica Superior/complicações , Doença Aguda , Idoso , Amilases/sangue , Feminino , Humanos , Infarto/diagnóstico , Infarto/patologia , Pancreatite/diagnóstico , Pancreatite/patologia , Síndrome da Artéria Mesentérica Superior/diagnóstico , Síndrome da Artéria Mesentérica Superior/patologiaRESUMO
Goodpasture's syndrome is characterised clinically by the association of haemoptysis and haematuria and is therefore the expression of lesions localised in two different apparatus, the respiratory and the renal, with an autoimmune type mechanism (production of circulating antibodies against the glomerular and alveolar basal membrane). A case of Goodpasture's syndrome in a male of 28 is reported in which the two basic clinical signs were not in evidence, making differential diagnosis more complicated.
Assuntos
Doença Antimembrana Basal Glomerular/diagnóstico , Adulto , Diagnóstico Diferencial , Humanos , MasculinoRESUMO
The long-term, epidural administration of morphine and marcaine (bupivacaine) in 12 patients suffering from bronchogenic carcinoma of the pulmonary apex and consequent Pancoast's syndrome has been examined. In 75% of cases the technique provided satisfactory results and the administration system was well tolerated by the patient.
Assuntos
Analgesia Epidural/métodos , Bupivacaína/administração & dosagem , Carcinoma Broncogênico/complicações , Neoplasias Pulmonares/complicações , Morfina/administração & dosagem , Síndrome de Pancoast/terapia , Idoso , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome de Pancoast/etiologia , Fatores de TempoRESUMO
Eleven patients suffering from seriously hypoxaemic chronic respiratory insufficiency with slight hypercapnia have been assessed. A comparison between the results obtained with continuous oxygen therapy carried out with a Ventury mask and that done with the Ventimask was made in the case of each patient. Distribution of O2 with the Ventimask made it possible to obtain higher average pO2 levels than with the Ventury mask.
Assuntos
Pneumopatias Obstrutivas/terapia , Máscaras , Oxigenoterapia/instrumentação , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Pressão ParcialRESUMO
Although the immunofluorescence technique has mostly been applied to renal diseases, it may be of use in the examination of lung tissue. Immunofluorescence tests on bronchial bioptic samples can show: 1) presence of IgE, IgA, IgM, IgG and complement factors; 2) their location on the bronchial mucosa; 3) their relationships with epithelioid cells, mast cells and plasma cells. Patients with atopic asthma were examined. Bioptic samples were taken from the main bronchi and treated by immunofluorescence. Cellular positivity was found for IgE, IgA, IgM and complement components.
Assuntos
Asma/diagnóstico , Brônquios/imunologia , Biópsia , Brônquios/patologia , Broncoscopia , Proteínas do Sistema Complemento/análise , Estudos de Avaliação como Assunto , Tecnologia de Fibra Óptica , Imunofluorescência , Humanos , Imunoglobulinas/análiseRESUMO
The diagnostic efficacy of percutaneous needle biopsy (PNB) was assessed in 220 lung tumour patients. The results obtained prove this diagnostic technique to be extremely sensitive even though personal experience suggests that slight complications (pneumothorax, homophthoe) may occur.
Assuntos
Biópsia por Agulha , Neoplasias Pulmonares/patologia , Pulmão/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia por Agulha/efeitos adversos , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pneumotórax/etiologiaRESUMO
A study was conducted on 20 patients with isolated or multiple patches of doubtful significance in the framework of neoplastic or infectious pathologies or in the presence of probably infectious diffuse or localised pulmonary infiltrations in immunodepressed patients or those in whom broad spectrum antibiotic treatment had failed. Percutaneous needle aspiration and sterile brushing was performed for the purpose of bacteriological examination in all patients. The result showed the clear superiority of needle aspiration (75% positive) over sterile brushing (25%). The first method is therefore recommended for use in the diagnosis of so-called "difficult" lung pathologies.
Assuntos
Infecções Bacterianas/patologia , Biópsia por Agulha , Pneumopatias/patologia , Adulto , Idoso , Infecções Bacterianas/microbiologia , Broncoscopia , Feminino , Tecnologia de Fibra Óptica , Humanos , Pulmão/microbiologia , Pulmão/patologia , Pneumopatias/microbiologia , Masculino , Pessoa de Meia-IdadeRESUMO
The role of echography in the study of the thorax is evaluated: after reporting the technical limits due to the peculiar anatomy of this region, personal experience is presented. This method extremely precise to define the solid or liquid nature of tightly adherent to the chest wall lesions, but it is non specific to assess their benign or malignant behaviour. Ultrasounds have their on limits in drawing the extension of such lesions; these limits have been overcome by CT and MR. Finally the usefulness of the method in studying the diaphragm and its pathology is briefly described.
Assuntos
Doenças Torácicas/diagnóstico , Ultrassonografia , Estudos de Avaliação como Assunto , HumanosRESUMO
Endobronchial metastases account for about 5% of autoptic findings in patients with multiple secondary locations. Five cases are reported of patients with malignant neoplasms in various organs with metastases to the trachea and the large bronchi without involvement of the pulmonary parenchyma and therefore with negative radiographic and CT scan findings.
Assuntos
Neoplasias Brônquicas/secundário , Adenocarcinoma/patologia , Idoso , Neoplasias da Mama/patologia , Neoplasias Brônquicas/patologia , Feminino , Humanos , Leiomiossarcoma/patologia , Pessoa de Meia-Idade , Neoplasias Retroperitoneais/patologia , Neoplasias da Glândula Tireoide/patologiaRESUMO
A case of IgD myeloma that began with high paraproteinaemia, BJ proteinuria of type and 40% marrow plasmacellular infiltration is reported. These onset data suggested a large tumoral mass and hence a poor prognosis. On the other hand, after subjecting the patient to 4 polychemotherapy cycles (alkeran and prednisone) CM disappeared from serum and urine and bone lesion progression stopped. It is also stressed that this from presents clinical (frequent extra-osseous growth, presence of amyloidosis), laboratory (severe anaemia, renal insufficiency, BJ proteinuria) and particular prognostic features.
Assuntos
Imunoglobulina D , Mieloma Múltiplo , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Humanos , Masculino , Melfalan/administração & dosagem , Mieloma Múltiplo/diagnóstico , Mieloma Múltiplo/tratamento farmacológico , Prednisona/administração & dosagem , PrognósticoRESUMO
The usefulness of ultrasonic studies for guiding the needle during biopsy of solid lesions or evacuation of saccate effusions and empyemas. Is a explained possible diagnostic protocol is then proposed which includes the ultrasonic examination in the diagnostic approach to parietal, mediastinic or diaphragmatic lesions.
Assuntos
Biópsia/métodos , Doenças Torácicas/patologia , Tórax/patologia , Ultrassom , HumanosRESUMO
An in vitro analysis was conducted to investigate the hypothetical antibacterial and antimycotic activity of the common anesthetic gases (halothane, enflurane, isoflurane, methoxyflurane) in view of the clinical absence of bronchopulmonary pathology after inhalation narcosis despite the many risk factors involved. For this purpose scalar dilutions of the four gases were prepared on cultures of Klebsiella pneumoniae and Candida albicans and the antibacterial action of the gases was tested in vitro. Even with the weaker concentrations used, halothane and methoxyflurane totally inhibited both microorganisms. Enflurane had less effect on Klebsiella p. and almost none on Candida. Isoflurane, a new halogen ether anesthetic was found to have an excellent inhibitory effect. In conclusion it is hypothesised that the anesthetic gases considered might have an in vivo antibacterial activity considering the experimental results obtained in vitro.
Assuntos
Anestésicos/farmacologia , Candida albicans/efeitos dos fármacos , Klebsiella pneumoniae/efeitos dos fármacos , Enflurano/farmacologia , Halotano/farmacologia , Humanos , Isoflurano/farmacologia , Metoxiflurano/farmacologiaRESUMO
The Authors report a case of familial mediterranean fever with pseudo-acute abdomen recently observed and emphasize how a careful anamnesis can avoid unnecessary surgical intervention.