Detalhe da pesquisa
1.
Insulin Prevents Hypercholesterolemia by Suppressing 12α-Hydroxylated Bile Acids.
Circulation
; 145(13): 969-982, 2022 03 29.
Artigo
Inglês
| MEDLINE | ID: mdl-35193378
2.
Antisense technology: A review.
J Biol Chem
; 296: 100416, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33600796
3.
Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice.
J Lipid Res
; 62: 100101, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34371033
4.
Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.
Arterioscler Thromb Vasc Biol
; 40(5): 1311-1324, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32188273
5.
Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
PLoS Genet
; 14(10): e1007732, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30372444
6.
Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.
N Engl J Med
; 377(3): 222-232, 2017 07 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28538111
7.
Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels.
Nucleic Acids Res
; 45(16): 9528-9546, 2017 Sep 19.
Artigo
Inglês
| MEDLINE | ID: mdl-28934489
8.
Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.
N Engl J Med
; 373(5): 438-47, 2015 Jul 30.
Artigo
Inglês
| MEDLINE | ID: mdl-26222559
9.
Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice.
Hepatology
; 65(3): 836-852, 2017 03.
Artigo
Inglês
| MEDLINE | ID: mdl-27862118
10.
Apolipoprotein CIII links islet insulin resistance to ß-cell failure in diabetes.
Proc Natl Acad Sci U S A
; 112(20): E2611-9, 2015 May 19.
Artigo
Inglês
| MEDLINE | ID: mdl-25941406
11.
The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
J Lipid Res
; 58(2): 420-432, 2017 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27941027
12.
Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation.
J Biol Chem
; 291(3): 1115-22, 2016 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26511317
13.
Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials.
Lancet
; 388(10057): 2239-2253, 2016 11 05.
Artigo
Inglês
| MEDLINE | ID: mdl-27665230
14.
Targeting APOC3 in the familial chylomicronemia syndrome.
N Engl J Med
; 371(23): 2200-6, 2014 Dec 04.
Artigo
Inglês
| MEDLINE | ID: mdl-25470695
15.
Angiotensinogen Exerts Effects Independent of Angiotensin II.
Arterioscler Thromb Vasc Biol
; 36(2): 256-65, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26681751
16.
Antisense inhibition of apolipoprotein (a) to lower plasma lipoprotein (a) levels in humans.
J Lipid Res
; 57(3): 340-51, 2016 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-26538546
17.
Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.
Lancet
; 386(10002): 1472-83, 2015 Oct 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26210642
18.
Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9.
Arterioscler Thromb Vasc Biol
; 35(7): 1589-96, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-26023080
19.
Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans.
Circ Res
; 112(11): 1479-90, 2013 May 24.
Artigo
Inglês
| MEDLINE | ID: mdl-23542898
20.
Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice.
J Lipid Res
; 55(3): 540-8, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24474819