Detalhe da pesquisa
1.
Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.
Bioorg Med Chem Lett
; 23(23): 6363-9, 2013 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24138939
2.
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.
Bioorg Med Chem Lett
; 22(16): 5303-7, 2012 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22795627
3.
Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors.
Bioorg Med Chem Lett
; 20(13): 3925-9, 2010 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20570147
4.
7-fluoroindazoles as potent and selective inhibitors of factor Xa.
J Med Chem
; 51(2): 282-97, 2008 Jan 24.
Artigo
Inglês
| MEDLINE | ID: mdl-18159923
5.
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.
Bioorg Med Chem Lett
; 18(5): 1603-6, 2008 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18242991
6.
Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.
Bioorg Med Chem Lett
; 18(5): 1642-8, 2008 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18242992
7.
Structure-based optimization of a potent class of arylamide FMS inhibitors.
Bioorg Med Chem Lett
; 18(12): 3632-7, 2008 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18495479
8.
Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
J Med Chem
; 54(22): 7860-83, 2011 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-22039836
9.
Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.
J Med Chem
; 53(4): 1843-56, 2010 Feb 25.
Artigo
Inglês
| MEDLINE | ID: mdl-20102150
10.
Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
J Med Chem
; 52(4): 1081-99, 2009 Feb 26.
Artigo
Inglês
| MEDLINE | ID: mdl-19193011
11.
The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.
Bioorg Med Chem Lett
; 16(22): 5778-83, 2006 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16949284
12.
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 16(1): 123-8, 2006 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-16236500
13.
A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s.
Bioorg Med Chem Lett
; 16(8): 2200-4, 2006 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16460935
14.
A novel series of potent and selective small molecule inhibitors of the complement component C1s.
Bioorg Med Chem Lett
; 14(12): 3043-7, 2004 Jun 21.
Artigo
Inglês
| MEDLINE | ID: mdl-15149641