Detalhe da pesquisa
1.
Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.
Bioorg Med Chem
; 91: 117386, 2023 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37379621
2.
Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy.
Bioorg Chem
; 120: 105604, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35051708
3.
Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors.
Eur J Med Chem
; 250: 115190, 2023 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36801518
4.
Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3ß inhibitory and neuroprotective activities against Alzheimer's disease.
Eur J Med Chem
; 256: 115415, 2023 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37172476
5.
Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer.
Eur J Med Chem
; 261: 115843, 2023 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37832229
6.
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
Eur J Med Chem
; 238: 114462, 2022 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35623249
7.
Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.
J Med Chem
; 65(19): 12838-12859, 2022 10 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36153841
8.
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
J Med Chem
; 64(23): 17304-17325, 2021 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34847663