A Survey on Analog-to-Digital Converter Integrated Circuits for Miniaturized High Resolution Ultrasonic Imaging System.

As traditional ultrasonic imaging systems (UIS) are expensive, bulky, and power-consuming, miniaturized and portable UIS have been developed and widely utilized in the biomedical field. The performance of integrated circuits (ICs) in portable UIS obviously affects the effectiveness and quality of ultrasonic imaging. In the ICs for UIS, the analog-to-digital converter (ADC) is used to complete the conversion of the analog echo signal received by the analog front end into digital for further processing by a digital signal processing (DSP) or microcontroller unit (MCU). The accuracy and speed of the ADC determine the precision and efficiency of UIS. Therefore, it is necessary to systematically review and summarize the characteristics of different types of ADCs for UIS, which can provide valuable guidance to design and fabricate high-performance ADC for miniaturized high resolution UIS. In this paper, the architecture and performance of ADC for UIS, including successive approximation register (SAR) ADC, sigma-delta (Σ-∆) ADC, pipelined ADC, and hybrid ADC, have been systematically introduced. In addition, comparisons and discussions of different types of ADCs are presented. Finally, this paper is summarized, and presents the challenges and prospects of ADC ICs for miniaturized high resolution UIS.

Echo Signal Receiving and Data Conversion Integrated Circuits for Portable High-Frequency Ultrasonic Imaging System.

Ultrasonic imaging has become a very promising technology, and it has been widely applied in biomedicine, geology, and other fields due to its advantages of safety, nondamaging, and real time. Especially, the portable high-frequency (>20 MHz) ultrasonic imaging system (UIS) has been generally used in biomedical detection and diagnosis. In the complex actual environment, the effect of integrated circuits (ICs) on the performance of portable high-frequency UIS is obvious. In the echo signal transmission link, the analog front end (AFE) and the analog-to-digital converter (ADC) are the two most critical modules, where AFE is used to receive and preprocess the analog ultrasonic echo signals and ADC to convert the analog signals from the AFE output to digital. The structure and performance of the ICs integrated into terminal equipment and in-probe for the portable high-frequency UIS are introduced and discussed. Some typical commercial ICs are also summarized. Based on the requirements and challenges of portable high-frequency UIS, the future development directions of ICs mainly include high integration, ultralow power consumption, high speed, and high precision, which can provide valuable reference and advice for the design of AFE and ADC for portable high-frequency UIS.

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44.

Lung cancer is the leading cause of cancer-related deaths worldwide, with 50-70% of patients suffering from bone metastasis. Accumulating evidence has demonstrated that miRNAs are involved in cell proliferation, migration, and invasion in malignancy, such as lung cancer bone metastasis. In the present study, we demonstrated that reduced miR-192-5p and increased TRIM44 levels were associated with the proliferation, migration and invasion of lung cancer. Furthermore, the potential functions of miR-192-5p were explored in A549 and NCI-H1299 cells. We found that miR-192-5p upregulation suppressed tumour behaviours in lung cancer cells. To further investigate whether miR-192-5p is associated with TRIM44, we used TargetScan software to predict the binding site between miR-192-5p and TRIM44. Luciferase activity assays were performed to verify this prediction. In addition, the significant role of miR-192-5p in negatively regulating TRIM44 expression was manifested by our research group. our results suggest that miR-192-5p inhibited the proliferation, migration and invasion of lung cancer through TRIM44.

Correlation of particle properties with cytotoxicity and cellular uptake of hydroxyapatite nanoparticles in human gastric cancer cells.

Three types of hydroxyapatite nanoparticles (HAPNs) were synthesized employing a sonochemistry-assisted microwave method by changing microwave power (from 200 to 300W) or using calcination treatment: L200 (200W, lyophilization), L300 (300W, lyophilization) and C200 (200W, lyophilization & calcination). Their physiochemical properties were characterized and correlated with cytotoxicity to human gastric cancer cells (MGC80-3). The major differences among these HAPN preparations were their size and specific surface area, with the L200 showing a smaller size and higher specific surface area. Although all HAPNs inhibited cell proliferation and induced apoptosis of cancer cells, L200 exhibited the greatest toxicity. All types of HAPNs were internalized through energy-dependent pathways, but the L200 nanoparticles were more efficiently uptaken by MGC80-3 cells. Inhibitor studies with dynasore and methyl-ß-cyclodextrin suggested that caveolae-mediated endocytosis and, to a much lesser extent, clathrin-mediated endocytosis, were involved in cellular uptake of the various preparations, whereas the inhibition of endocytosis was more obvious for L200. Using fluorescein isothiocyanate-labeled HAPNs and laser-scanning confocal microscopy, we found that all forms of nanoparticles were present in the cytoplasm, and some L200 HAPNs were even found within nuclei. Treatment with all HAPN preparations led to the increase in the intracellular calcium level with the highest level detected for L200.

Attaching double chain cationic Gd(iii)-containing surfactants on nanosized colloids for highly efficient MRI contrast agents.

A new Gd(iii)-based metallosurfactant with double quaternary-ammonium-containing long alkyl chains was developed and subjected to the miniemulsion polymerization of vinyl monomers, giving nanosized colloids (50-110 nm) with narrow size distribution. The size of the colloid particles can be easily tuned by adjusting the feeding ratio of metallosurfactant to monomer. SEM and XPS analysis showed that the Gd(iii) complexes were attached on the surface of the colloids. ICP-AES analysis further quantified the contents of Gd(iii) in the miniemulsions. T1 magnetic resonance imaging (MRI) showed that these Gd(iii)-loading colloids exhibited relaxivity of up to 22.77 mM-1 s-1, much higher than that of Ominiscan® (4.64 mM-1 s-1).