Heavy Chronic Ethanol Exposure From Adolescence to Adulthood Induces Cerebellar Neuronal Loss and Motor Function Damage in Female Rats.

Over the last years, heavy ethanol consumption by teenagers/younger adults has increased considerably among females. However, few studies have addressed the long-term impact on brain structures' morphology and function of chronic exposure to high ethanol doses from adolescence to adulthood in females. In line with this idea, in the current study we investigated whether heavy chronic ethanol exposure during adolescence to adulthood may induce motor impairments and morphological and cellular alterations in the cerebellum of female rats. Adolescent female Wistar rats (35 days old) were treated with distilled water or ethanol (6.5 g/kg/day, 22.5% w/v) during 55 days by gavage. At 90 days of age, motor function of animals was assessed using open field (OF), pole, beam walking and rotarod tests. Following completion of behavioral tests, morphological and immunohistochemical analyses of the cerebellum were performed. Chronic ethanol exposure impaired significantly motor performance of female rats, inducing spontaneous locomotor activity deficits, bradykinesia, incoordination and motor learning disruption. Moreover, histological analysis revealed that ethanol exposure induced atrophy and neuronal loss in the cerebellum. These findings indicate that heavy ethanol exposure during adolescence is associated with long-lasting cerebellar degeneration and motor impairments in female rats.

Ações de Cuidados para Alta Hospitalar do Paciente Cirúrgico / Care Actions for Surgical Patients Discharge

Esta cartilha é destinada aos usuários que se submeteram a intervençõescirúrgicasinternados nas Unidades de Terapia Intensiva do Hospital de Alta Complexidade Dr. Carlos Macieira, São Luís/MA. O objetivo é repassar de forma clara e objetiva informações simples e seguras sobre os cuidados no pós-operatório durante seu processo de reabilitaçãoem domicílio.Este informativo foi construído num coletivo composto por profissionais das áreas de enfermagem, nutrição, odontologia e fisioterapia do Programa de Residência Multiprofissional em Terapia Intensiva da Secretaria de Estado do Maranhãocomapoio da Empresa Maranhense de Serviços hospitalares (EMSERH).