RESUMO
We have discussed some of the methods that might be used in approaching fiscal control of the anatomic pathology laboratory. The pathologist, in a unique position as manager and physician, must assume a leadership role in this area. Now more than ever, these qualities must be used to direct the laboratory to a more productive and cost efficient plane.
Assuntos
Laboratórios/organização & administração , Patologia Cirúrgica/economia , Controle de Custos/métodos , Custos e Análise de Custo , Equipamentos e Provisões , Serviço Hospitalar de Patologia/organização & administração , Gestão de Recursos Humanos/economia , Estados UnidosRESUMO
Estrogen and progesterone binding sites were assayed in patients with primary, recurrent and metastatic mammary carcinoma using a new histochemical technique. This histochemical assay employed fluorescein-labeled conjugates of bovine serum albumin covalently bound to estradiol or progesterone. In a double-blind study in which the results of histochemistry were correlated with those obtained by a conventional biochemical assay, there was 83% correlation for estrogen binding in 41 cases and 87% correlation for progesterone binding in 31 cases.
Assuntos
Neoplasias da Mama/metabolismo , Estrogênios/metabolismo , Progesterona/metabolismo , Receptores de Estrogênio/análise , Receptores de Progesterona/análise , Sítios de Ligação , Biópsia por Agulha , Nucléolo Celular/metabolismo , Núcleo Celular/metabolismo , Citoplasma/metabolismo , Método Duplo-Cego , Estudos de Avaliação como Assunto , Feminino , Histocitoquímica , HumanosRESUMO
Penile condyloma acuminatum is a rare pediatric entity. We report on a 17-month-old boy with penile and urethral condyloma acuminatum. The presence of cervical dysplasia in a histological setting suggestive of condyloma in his mother supports congenital acquisition of the disease. Histological and histochemical evidence for a viral etiology of the disease in the mother and patient is presented.
Assuntos
Condiloma Acuminado/patologia , Recidiva Local de Neoplasia/patologia , Neoplasias Penianas/patologia , Pênis/patologia , Adulto , Biópsia , Colo do Útero/patologia , Condiloma Acuminado/congênito , Feminino , Humanos , Corpos de Inclusão Viral/ultraestrutura , Lactente , Masculino , Papillomaviridae , Neoplasias Penianas/congênito , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Infecções Tumorais por Vírus/patologia , Displasia do Colo do Útero/patologiaRESUMO
A 35-year-old man who received radiation for thymic enlargement as a child and subsequently developed both thyroid and breast cancer is reported. This appears to be the first case in which this association has been reported in a male.