RESUMO
A thiaether metal complex 1-aza-4,7-dithiacyclononane-RhCl3, 2, and cyclic amine metal complexes tacn-CuBr2, 3, and Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancer cell line NuTu-19 and for cell toxicity against the noncancerous ovarian tissue cell line OVepi. Specifically, metal complex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasion assay. The in vitro results reported warrant further evaluation of metal complex 2 in living systems.
Assuntos
Antineoplásicos/síntese química , Compostos Organometálicos/síntese química , Ródio , Animais , Antineoplásicos/química , Antineoplásicos/farmacologia , Linhagem Celular , Linhagem Celular Tumoral , Cobre , Ensaios de Seleção de Medicamentos Antitumorais , Feminino , Compostos Organometálicos/química , Compostos Organometálicos/farmacologia , Neoplasias Ovarianas , Ratos , Ratos Endogâmicos F344 , Rutênio , Relação Estrutura-AtividadeRESUMO
The reaction of 4-ethynyl-pyridine with tert-butyl lithium followed by its addition to (Me3tacn)RhCl3 affords the facial octahedral complex (Me3tacn)Rh(CCPy)3, condensation of which with the square planar complex cis-(DCPE)Pt(NO3)2 results in a self-assembled trigonal bipyramidal cage with Rh(III) and Pt(II) atoms occupying the vertices.
Assuntos
Compostos Organometálicos/química , Compostos Organometálicos/síntese química , Platina/química , Piridinas/química , Ródio/química , Cristalografia por Raios X , Substâncias Macromoleculares/química , Modelos Moleculares , Conformação MolecularRESUMO
Addition of AgBF4 or Ag(O3SCF3) to the tripodal ligand, Me3tacnRh(CCPh)3, yields a paddlane complex as well as a novel trinuclear silver "tweezer" complex based upon silver acetylene coordination chemistry. The paddlane is composed of two Me3tacnRh(CCPh)3 moieties held together by silver acetylene interactions. The tweezer complex is composed of one tripodal moiety with three silver atoms coordinated to each acetylene-Rh-acetylene face. The tweezer complex is stabilized by additional interactions, including a triflate anion which serves to cap the complex.