Detalhe da pesquisa
1.
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies.
Parasitology
; 147(11): 1216-1228, 2020 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32530391
2.
In vitro and in silico analysis of imatinib analogues as anti-Trypanosoma cruzi drug candidates.
Parasitology
; : 1-18, 2023 Jan 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36632017
3.
Biological approaches to characterize the mode of action of two 5-nitroindazolinone prototypes on Trypanosoma cruzi bloodstream trypomastigotes.
Parasitology
; 143(11): 1469-78, 2016 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27312370
4.
In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi.
Antimicrob Agents Chemother
; 58(7): 3720-6, 2014 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-24752263
5.
Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo.
Antimicrob Agents Chemother
; 57(11): 5307-14, 2013 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-23939901
6.
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Antimicrob Agents Chemother
; 57(9): 4151-63, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23774435
7.
Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
Antimicrob Agents Chemother
; 56(7): 3690-9, 2012 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22508306
8.
In vitro trypanocidal activity of DB745B and other novel arylimidamides against Trypanosoma cruzi.
J Antimicrob Chemother
; 66(6): 1295-7, 2011 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-21478242
9.
The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro.
Parasitology
; 138(14): 1863-9, 2011 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-21902869
10.
The biological in vitro effect and selectivity of aromatic dicationic compounds on Trypanosoma cruzi.
Mem Inst Oswaldo Cruz
; 105(3): 239-45, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20512235
11.
Trypanosoma cruzi: activity of heterocyclic cationic molecules in vitro.
Exp Parasitol
; 123(1): 73-80, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19520077
12.
Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents.
J Med Chem
; 62(19): 8847-8865, 2019 10 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31495177
13.
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
ACS Infect Dis
; 5(3): 365-371, 2019 03 08.
Artigo
Inglês
| MEDLINE | ID: mdl-30625275
14.
In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi.
Antimicrob Agents Chemother
; 52(9): 3307-14, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18625779
15.
Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.
J Med Chem
; 61(23): 10910-10921, 2018 12 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30451500
16.
Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration.
Eur J Med Chem
; 149: 257-268, 2018 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29501946
17.
Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study.
J Venom Anim Toxins Incl Trop Dis
; 24: 30, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30450114
18.
New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations.
Chem Biol Drug Des
; 92(3): 1670-1682, 2018 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29745048
19.
Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.
Drug Des Devel Ther
; 11: 1095-1105, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28435221
20.
Ciprofloxacin Derivatives Affect Parasite Cell Division and Increase the Survival of Mice Infected with Toxoplasma gondii.
PLoS One
; 10(5): e0125705, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25950173