Investigating the effect of clay content and type on the mechanical performance of calcium alginate-based hybrid bio-capsules.

This study aims to investigate the mechanical behavior of alginate-based simple and alginate@clay-based hybrid capsules under uniaxial compression using a Brookfield force machine. The effect of clay type and content on Young's modulus and nominal rupture stress of the capsules was investigated and characterized using Scanning Electron Microscopy (SEM), and Fourier Transform Infrared Spectroscopy (ATR-FTIR). Results showed that clay content improves the mechanical properties depending on its type. Montmorillonite and laponite clays showed optimal results at 3 wt% content, with a gain of 63.2 % and 70.34 % on Young's modulus, and a gain of 92.43 % and 108.66 % on nominal rupture stress, respectively, while kaolinite clay showed optimal results at 1.5 wt% content with an increase of 77.21 % on Young's modulus and 88.34 % on nominal rupture stress. However, exceeding the optimal content led to decrease the elasticity and rigidity due to the incomplete dispersion of clay particles in the hydrogel network. The theoretical modeling using Boltzmann superposition principle revealed that the elastic modulus was in good agreement with experimental values. Overall, this research provides insights into the mechanical behavior of alginate@clay-based capsules, which could have potential applications in drug delivery systems and tissue engineering.

Gas chromatography coupled to mass spectrometry characterization, anti-inflammatory effect, wound-healing potential, and hair growth-promoting activity of Algerian Carthamus caeruleus L (Asteraceae).

OBJECTIVES: The roots of Carthamus caeruleus have been used by the population of Northern Algeria to treat several pathological conditions, including wound healing and hair growth. The present study was conducted to evaluate the anti-inflammatory activity, wound-healing potential, and hair growth-promoting activity attributed to C. caeruleus root. MATERIALS AND METHODS: In this study, we have investigated the anti-inflammatory effect using carrageenan-induced paw edema test, evaluated the wound-healing potential by linear incision wound model, and evaluated hair growth activity using in vivo hair growth-promoting test attributed to C. caeruleus root. Preliminary phytochemical screening and gas chromatography coupled to mass spectrometry (GC/MS) characterization were also performed. RESULTS: It was found that the methanolic extract of C. caeruleus was characterized by the presence of tannins, flavonoids, anthocyanins, leucoanthocyanins, sennosides, free quinones, saponins, glycosides, mucilage, and coumarins. The GC/MS analysis could identify 22 compounds and showed that the major chemical constituents were palmitic acid (12.88%), mono(2-ethylhexyl) phthalate (12.75%), and 5-(hydroxymethyl)-2-furancarboxaldehyde, (9.19%). The phytoextract strongly inhibited (P < 0.001) paw edema formation in mice. The roots of C. caeruleus also showed a significant (P < 0.05) wound-healing and hair growth-promoting effects. CONCLUSION: The results indicate the richness of the roots of the Algerian C. caeruleus in biomolecules. These molecules exhibit an excellent reducing inflammation activity, a wound-healing property, and an interesting hair-promoting growth activity. All in all, the findings promote the usage of the Algerian C. caeruleus as an effective and a safe potential skincare alternative remedy.

Thermoreversible gelation in aqueous binary solvents of chemically modified agarose.

The thermoreversible gelation of chemically modified agarose has been studied in aqueous binary solvents (dimethyl sulfoxide and a series of formamide) by differential calorimetry, mechanical testing, and small-angle neutron scattering. The temperature-composition phase diagrams have been established. It is concluded that gelation is promoted by the formation of ternary complexes modified agarose/water/cosolvent, wherein the cosolvent mediates the interaction between chains through the formation of electrostatic interactions.