1.
Angew Chem Int Ed Engl
; 60(34): 18572-18576, 2021 08 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34164892
RESUMO
3-Deoxyfortalpinoidâ F, fortalpinoidâ A, and cephinoidâ H are members of the Cephalotaxus diterpenoids class of natural products, which feature diverse chemical structures and valuable biological activities. We report herein the development of a diastereoselective Pauson-Khand reaction as an effective pathway to access the core tetracyclic skeleton, which is found widely in Cephalotaxus diterpenoids. Furthermore, we enabled the construction of the tropone moiety through a ring-closing metathesis/elimination protocol. Based on the developed strategy, asymmetric synthesis of the title compounds has been achieved for the first time.