Detalhe da pesquisa
1.
Clinical activity and safety of the anti-PD-1 monoclonal antibody dostarlimab for patients with recurrent or advanced dMMR endometrial cancer.
Future Oncol
; 17(29): 3781-3785, 2021 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34427115
2.
Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C.
Invest New Drugs
; 35(2): 235-241, 2017 04.
Artigo
Inglês
| MEDLINE | ID: mdl-28188407
3.
A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C.
Invest New Drugs
; 35(5): 634-641, 2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28527133
4.
Sequence analysis of ß-subunit genes of the 20S proteasome in patients with relapsed multiple myeloma treated with bortezomib or dexamethasone.
Blood
; 120(23): 4513-6, 2012 Nov 29.
Artigo
Inglês
| MEDLINE | ID: mdl-23018640
5.
Phase I study of MLN8237--investigational Aurora A kinase inhibitor--in relapsed/refractory multiple myeloma, non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Invest New Drugs
; 32(3): 489-99, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24352795
6.
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
Gynecol Oncol
; 127(1): 63-9, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22772063
7.
Safety, antitumor activity, and pharmacokinetics of dostarlimab, an anti-PD-1, in patients with advanced solid tumors: a dose-escalation phase 1 trial.
Cancer Chemother Pharmacol
; 89(1): 93-103, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34750637
8.
Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models.
MAbs
; 13(1): 1954136, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34313545
9.
Clinical Activity and Safety of the Anti-Programmed Death 1 Monoclonal Antibody Dostarlimab for Patients With Recurrent or Advanced Mismatch Repair-Deficient Endometrial Cancer: A Nonrandomized Phase 1 Clinical Trial.
JAMA Oncol
; 6(11): 1766-1772, 2020 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33001143
10.
TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-Label, Non-randomized Phase 1 Study.
Cancer Res Treat
; 50(2): 398-404, 2018 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-28494535
11.
Evaluation of TAK-264, an Antibody-Drug Conjugate in Pancreatic Cancer Cell Lines and Patient-Derived Xenograft Models.
Clin Cancer Drugs
; 5(1): 42-49, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30631747
12.
A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo.
PLoS One
; 13(1): e0191046, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-29370189
13.
Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer.
Cancer Res
; 65(16): 7081-5, 2005 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16103055
14.
Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers.
PLoS One
; 12(12): e0189953, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-29261789
15.
Use of the Total Cancer Care System to Enrich Screening for CD30-Positive Solid Tumors for Patient Enrollment Into a Brentuximab Vedotin Clinical Trial: A Pilot Study to Evaluate Feasibility.
JMIR Res Protoc
; 6(3): e45, 2017 Mar 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28320689
16.
Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor.
EBioMedicine
; 25: 50-57, 2017 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-29122619
17.
Allelic loss at Drosophila patched gene is highly prevalent in Basal and squamous cell carcinomas of the skin.
J Invest Dermatol
; 126(5): 1152-8, 2006 May.
Artigo
Inglês
| MEDLINE | ID: mdl-16484983
18.
Development and Validation of an ERCC1 Immunohistochemistry Assay for Solid Tumors.
Arch Pathol Lab Med
; 140(12): 1397-1403, 2016 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-27610644
19.
Microsatellite instability at tetranucleotide repeats in skin and bladder cancer.
Oncogene
; 21(32): 4894-9, 2002 Jul 25.
Artigo
Inglês
| MEDLINE | ID: mdl-12118368
20.
Dose selection for the investigational anticancer agent alisertib (MLN8237): Pharmacokinetics, pharmacodynamics, and exposure-safety relationships.
J Clin Pharmacol
; 55(3): 336-47, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25302940