Detalhe da pesquisa
1.
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
Cell
; 171(3): 642-654.e12, 2017 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-29053970
2.
Altered exocrine function can drive adipose wasting in early pancreatic cancer.
Nature
; 558(7711): 600-604, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29925948
3.
Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.
J Biol Chem
; 291(31): 16221-30, 2016 07 29.
Artigo
Inglês
| MEDLINE | ID: mdl-27226575
4.
Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.
Am J Physiol Endocrinol Metab
; 313(3): E303-E313, 2017 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28611026
5.
The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis.
J Biol Chem
; 290(24): 15175-84, 2015 Jun 12.
Artigo
Inglês
| MEDLINE | ID: mdl-25922078
6.
Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling.
J Lipid Res
; 54(10): 2697-707, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-23924694
7.
Effects of aging on glucose and lipid metabolism in mice.
bioRxiv
; 2023 Dec 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38187759
8.
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
Elife
; 92020 07 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32648540
9.
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.
Elife
; 82019 04 16.
Artigo
Inglês
| MEDLINE | ID: mdl-30990168
10.
Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer.
Cancer Epidemiol Biomarkers Prev
; 28(12): 2062-2069, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31533940
11.
Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies.
Dis Model Mech
; 11(8)2018 08 07.
Artigo
Inglês
| MEDLINE | ID: mdl-30104199
12.
PKM2 is not required for pancreatic ductal adenocarcinoma.
Cancer Metab
; 6: 17, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30386596
13.
Aspartate is an endogenous metabolic limitation for tumour growth.
Nat Cell Biol
; 20(7): 782-788, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29941931
14.
Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.
Elife
; 62017 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28826492
15.
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming.
Mol Metab
; 6(8): 781-796, 2017 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28752043
16.
Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells.
Dev Cell
; 36(5): 540-9, 2016 Mar 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26954548
17.
Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.
Mol Cell Biol
; 36(12): 1740-9, 2016 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27044870
18.
Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.
Mol Metab
; 5(12): 1149-1161, 2016 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27900258
19.
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
Science
; 353(6304): 1161-5, 2016 09 09.
Artigo
Inglês
| MEDLINE | ID: mdl-27609895
20.
Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues.
Mol Cell Biol
; 35(13): 2356-65, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25918248