A Comparative Assessment of Arsenic Risks and the Nutritional Benefits of Fish Consumption in Kuwait: Arsenic Versus Omega 3-Fatty Acids.

Inorganic and organic forms of arsenic (As), as well as omega-3 fatty acids were measured in 578 fish/seafood samples that belong to 15 species of commonly consumed seafood in Kuwait. Arsenic speciation data, with the toxicological profile of inorganic arsenic (iAs) and fish consumption rates were applied in a probabilistic risk assessment to estimate the risk from exposure to iAs. The nutritional benefits of omega-3-fatty acid levels in various species of fish were taken into consideration. Results showed that the mean daily intake of iAs through fish consumption among the Kuwaiti population was 0.058 µg/kg/day, and the 95th percentile was 0.15 µg/kg/day. Although the mean intake level did not exceed the incremental lifetime cancer risk (ILCR) at 1 × 10-4, the 95th percentile of iAs intake showed an ILCR of 2.7 × 10-4. Kuwaiti children (aged 6-12 years) were found to have a higher mean intake of iAs at 0.10 µg/kg/day with 68% of children in this category, exceeding the risk specific dose associated with an ILCR of 1 × 10-4. The fish species, hammor (grouper; Epinephelus coioides), is the top contributor to iAs intake, and tuna is the major source of omega 3-fatty acids for the Kuwaiti population.

Screening for PCDD/Fs and dl-PCBs in local and imported food and feed products available across the State of Kuwait and assessment of dietary intake.

A total of 318 local and imported meat, milk, eggs, fish, and animal feed samples collected in Kuwait were analyzed by cell-based reporter gene assay (Dioxin-Responsive Chemical Activated LUciferase gene eXpression DR-CALUX) for PCDD/Fs and dl-PCBs. The bioanalytical equivalents (BEQs) obtained by DR-CALUX bioassay were compared with the official maximum limits according to the European Commission (EC) regulations. Suspected and randomly chosen negative samples were analyzed by gas chromatography-high resolution mass spectrometry (GC-HRMS). The results showed that among suspected samples, one sample was confirmed to be non-compliant. The positive sample was of imported origin. The correlation coefficient of 0.98 between DR-CALUX and GC-HRMS was found. Moreover, the average daily intakes of PCDD/Fs and dl-PCBs for the Kuwaiti population were estimated. Results obtained in this study were discussed and compared with other published data.

Exposure and risk characterization for dietary methylmercury from seafood consumption in Kuwait.

Seafood is an important source of essential nutrients; however, it can also confer health risks from methylmercury (MeHg). In this paper, we evaluate the levels of potential methylmercury exposure among Kuwaiti seafood consumers in order to support the development of dietary recommendations for fish consumption in Kuwait. Total mercury (HgT) concentration for most of the studied fish and shellfish species were on average below the 0.5µgg-1 Codex guideline. The notable exception to this was Hamoor (Epinephelus coioides), which averaged 1.29µgg-1 HgT and 0.55µgg-1 MeHg. A dietary survey of 2393 households demonstrated that large quantities of fish and shellfish are commonly consumed in Kuwait (average consumption: 103gd-1). Most participants (53.6%) exceeded the Tolerable Daily Intake of MeHg; this percent exceedance was as high as 78% in children 6-12years of age. The majority (Mean: 50-51%) of Kuwaiti's dietary MeHg exposure comes from the consumption of Hamoor; therefore, advisories to limit the consumption of Hamoor may be necessary. Nutrient:Methylmercury ratios are reported herein; these ratios may assist efforts to create dietary advice that limits contaminant risk while promoting the nutritional benefits of seafood in Kuwait.