Detalhe da pesquisa
1.
Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model.
Br J Cancer
; 124(11): 1809-1819, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33742147
2.
Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor ß Superfamily Type 1 Receptors.
Mol Pharmacol
; 95(2): 222-234, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30459156
3.
Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL.
Blood
; 130(3): 310-322, 2017 07 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28202458
4.
Expression of Concern: Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
J Cell Sci
; 133(17)2020 09 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32917731
5.
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Breast Cancer Res
; 16(5): 430, 2014 Sep 11.
Artigo
Inglês
| MEDLINE | ID: mdl-25212826
6.
PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways.
Br J Haematol
; 167(1): 69-79, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-24975213
7.
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.
Biochem J
; 452(3): 499-508, 2013 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23581296
8.
Preclinical Characterization of AZD9574, a Blood-Brain Barrier Penetrant Inhibitor of PARP1.
Clin Cancer Res
; 30(7): 1338-1351, 2024 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37967136
9.
Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation.
Breast Cancer Res
; 15(4): R55, 2013.
Artigo
Inglês
| MEDLINE | ID: mdl-23844554
10.
The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere.
J Transl Med
; 11: 241, 2013 Oct 02.
Artigo
Inglês
| MEDLINE | ID: mdl-24088382
11.
MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells.
Cell Rep
; 42(5): 112484, 2023 05 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37163373
12.
Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
Eur J Cancer
; 190: 112950, 2023 09.
Artigo
Inglês
| MEDLINE | ID: mdl-37441939
13.
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.
ACS Med Chem Lett
; 13(8): 1295-1301, 2022 Aug 11.
Artigo
Inglês
| MEDLINE | ID: mdl-35978693
14.
AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kß/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.
Oncogene
; 41(46): 5046-5060, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36241868
15.
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Clin Cancer Res
; 27(15): 4353-4366, 2021 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34011558
16.
Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy.
Commun Biol
; 4(1): 112, 2021 01 25.
Artigo
Inglês
| MEDLINE | ID: mdl-33495510
17.
Emerging targeted therapies for bladder cancer: a disease waiting for a drug.
Cancer Metastasis Rev
; 28(3-4): 355-67, 2009 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-19997963
18.
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.
J Med Chem
; 63(7): 3461-3471, 2020 04 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31851518
19.
Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts.
Clin Cancer Res
; 26(14): 3720-3731, 2020 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32220884
20.
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.
Clin Cancer Res
; 26(24): 6535-6549, 2020 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-32988967