RESUMO
Serum of 37 brain tumour patients was studied for, Total protein, Protein electrophoresis, IgG, IgA, and IgM in an attempt to ascertain humoral immune response. Findings were compared with 20 healthy subjects, matched for age, sex and socioeconomic status. There was significant rise in alpha-II globulin, while IgG was suppressed in tumour patients. Decrease of IgG was more marked in patients with malignant tumours. Immunoglobulin A was low in children when compared with adults. Immunoglobulin M remained unchanged (JPMA 42: 157, 1992).
Assuntos
Neoplasias Encefálicas/imunologia , Imunoglobulina A/sangue , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Eletroforese das Proteínas Sanguíneas , Proteínas Sanguíneas/análise , Neoplasias Encefálicas/sangue , HumanosRESUMO
Ventricular CSF glucose, total protein, protein electrophoresis, IgG, IgA, IgM and CSF cytology were determined in thirty seven patients with brain tumours. CSF glucose was unchanged and total protein was significantly high. Protein electrophoresis showed higher albumin and gamma globulin fractions. Mean IgG and IgA were significantly higher (P less than 0.001) in malignant tumours than in benign ones. IgM was detectable in 7 of 37 cases. The higher concentration of total protein, albumin and gamma globulin shows some degree of impairment of blood brain barrier. Increased concentration of IgG, IgA and IgM indicates humoral immune response of the brain against the tumours.
Assuntos
Neoplasias Encefálicas/líquido cefalorraquidiano , Ventrículos Cerebrais/imunologia , Imunoglobulinas/líquido cefalorraquidiano , Adolescente , Adulto , Formação de Anticorpos , Neoplasias Encefálicas/imunologia , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
OBJECTIVE: To estimate different proteins and immunoglobulins as humoral immune response in patients with intracranial tumours. METHODS: Cellulose acetate membrane electrophoresis for estimation of different proteins and radialimmunodiffusion (RID) for measurement of serum and CSF immunoglobulins were used. RESULTS: Thirty seven patients with different types of tumours showed increase in serum alpha II globulin, significant decrease of IgG, in patients when compared with controls, significant decrease of IgG in malignant tumours compared with benign tumours. CSF albumin, gamma globulin, immunoglobulins G,A,and M were increased. CONCLUSION: Alpha II globulin, steroid therapy and active neoplasia may be responsible for decreased serum immunoglobulins, while raised gamma globulin and immunoglobulins with intact BBB indicates capability of CNS to produce immunoglobulins.