Detalhe da pesquisa
1.
Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider.
Proc Natl Acad Sci U S A
; 119(5)2022 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35074873
2.
Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans.
Proc Natl Acad Sci U S A
; 118(18)2021 05 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33893140
3.
Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain.
Int J Mol Sci
; 25(9)2024 Apr 26.
Artigo
Inglês
| MEDLINE | ID: mdl-38731963
4.
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.
Nature
; 534(7608): 494-9, 2016 06 23.
Artigo
Inglês
| MEDLINE | ID: mdl-27281198
5.
A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.
Proc Natl Acad Sci U S A
; 116(44): 22353-22358, 2019 10 29.
Artigo
Inglês
| MEDLINE | ID: mdl-31611414
6.
PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold.
Cell Mol Life Sci
; 75(24): 4511-4524, 2018 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-30109357
7.
Development of a µO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.
J Biol Chem
; 291(22): 11829-42, 2016 May 27.
Artigo
Inglês
| MEDLINE | ID: mdl-27026701
8.
Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.
Angew Chem Int Ed Engl
; 56(47): 14973-14976, 2017 11 20.
Artigo
Inglês
| MEDLINE | ID: mdl-28984021
9.
Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities.
Angew Chem Int Ed Engl
; 56(29): 8495-8499, 2017 07 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28513074
10.
Identification and Characterization of ProTx-III [µ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
Mol Pharmacol
; 88(2): 291-303, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-25979003
11.
Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl.
Angew Chem Int Ed Engl
; 53(11): 2931-4, 2014 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24604812
12.
Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability.
Org Biomol Chem
; 10(30): 5791-4, 2012 Aug 14.
Artigo
Inglês
| MEDLINE | ID: mdl-22581211
13.
Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor.
ACS Chem Neurosci
; 13(8): 1245-1250, 2022 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35357806
14.
The Tarantula Toxin ω-Avsp1a Specifically Inhibits Human CaV3.1 and CaV3.3 via the Extracellular S3-S4 Loop of the Domain 1 Voltage-Sensor.
Biomedicines
; 10(5)2022 May 04.
Artigo
Inglês
| MEDLINE | ID: mdl-35625803
15.
α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure.
J Am Chem Soc
; 133(40): 15866-9, 2011 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-21899353
16.
Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin.
Chem Sci
; 12(11): 4057-4062, 2021 Feb 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34163676
17.
The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation.
Front Pharmacol
; 12: 789570, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-35095499
18.
Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of NaV1.7.
Biomedicines
; 8(2)2020 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-32092883
19.
Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7.
Biochem Pharmacol
; 181: 114080, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32511987
20.
It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper Ant Myrmecia pilosula.
Biomedicines
; 8(7)2020 Jun 30.
Artigo
Inglês
| MEDLINE | ID: mdl-32629771