Detalhe da pesquisa
1.
5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors.
Bioorg Med Chem Lett
; 30(17): 127387, 2020 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32738984
2.
Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 29(20): 126668, 2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31519374
3.
Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.
Bioorg Med Chem Lett
; 29(15): 1974-1980, 2019 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31138472
4.
Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents.
J Pharmacol Exp Ther
; 365(3): 676-687, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29674332
5.
Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.
Bioorg Med Chem Lett
; 28(21): 3446-3453, 2018 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-30268701
6.
Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors.
Bioorg Med Chem Lett
; 28(7): 1182-1187, 2018 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29523385
7.
Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists.
Bioorg Med Chem Lett
; 27(8): 1760-1764, 2017 04 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28285911
8.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.
Bioorg Med Chem Lett
; 24(5): 1437-41, 2014 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24405703
9.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
Bioorg Med Chem Lett
; 23(24): 6773-6, 2013 Dec 15.
Artigo
Inglês
| MEDLINE | ID: mdl-24153205
10.
The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.
J Lipid Res
; 53(6): 1106-16, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22493088
11.
Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.
Bioorg Med Chem Lett
; 22(4): 1750-5, 2012 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22264481
12.
Phase 0 study of the inhibition of cholesteryl ester transfer protein activity by JNJ-28545595 in plasma from normolipidemic and dyslipidemic humans.
Int J Clin Pharmacol Ther
; 50(8): 584-94, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22578199
13.
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
Bioorg Med Chem Lett
; 21(10): 3134-41, 2011 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21444206
14.
Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.
J Cardiovasc Pharmacol
; 55(5): 459-68, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20051879
15.
Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors.
Bioorg Med Chem Lett
; 20(4): 1432-5, 2010 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20089400
16.
Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.
Bioorg Med Chem Lett
; 20(9): 2864-7, 2010 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20347304
17.
Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB1R Inverse Agonists.
ACS Med Chem Lett
; 11(12): 2504-2509, 2020 Dec 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33335674
18.
Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.
Bioorg Med Chem Lett
; 19(9): 2456-60, 2009 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19339179
19.
Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Bioorg Med Chem Lett
; 19(4): 1101-4, 2009 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19168353
20.
Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists.
Bioorg Med Chem Lett
; 19(14): 3977-80, 2009 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19217285