RESUMO
Acute myeloid leukemia with minimal signs of myeloid differentiation (AML-M0) is a recent addition to the FAB group classification. Chromosome data is scarce, but existing reports describe a high incidence of complex karyotypes and myelodysplastic syndrome-like chromosome alterations, while single chromosome translocations have rarely been reported. We describe the case of a 60-year-old woman diagnosed with AML-M0 with a novel translocation t(11;12)(q23-24;q24) as the sole karyotypic marker. Fluorescence in situ hybridization analysis to assess MLL gene splitting did not show rearrangement of this oncogene.
Assuntos
Cromossomos Humanos Par 11/genética , Cromossomos Humanos Par 12/genética , Leucemia Mieloide/genética , Leucemia Mieloide/patologia , Proto-Oncogenes , Fatores de Transcrição , Translocação Genética/genética , Doença Aguda , Diferenciação Celular , Bandeamento Cromossômico , Proteínas de Ligação a DNA/genética , Evolução Fatal , Feminino , Histona-Lisina N-Metiltransferase , Humanos , Hibridização in Situ Fluorescente , Cariotipagem , Leucemia Mieloide/tratamento farmacológico , Linfócitos/metabolismo , Pessoa de Meia-Idade , Síndromes Mielodisplásicas/genética , Proteína de Leucina Linfoide-Mieloide , RecidivaRESUMO
This study inquires if there is an increase of chromosomal aberrations by ionising radiation of cosmic origin in civil pilots and flight-crew members. Totals of 37,208 exposed cells and 10,950 control cells, from 192 and 55 donors respectively, were scored averaging 200 observations per subject. The analysis showed the increase of dicentric and ring chromosomes in peripheral blood lymphocytes of the flight personnel. The difference of the total aberration frequencies between exposed and control was statistically significant.