Investigation of drug interactions with pinaverium bromide.

A series of studies was carried out at 6 centres to investigate possible drug interaction between the spasmolytic, pinaverium bromide, and cardiac glycosides, anticoagulants and hypoglycaemic agents given to patients as part of the long-term treatment of their condition. The results of clinical and laboratory investigations did not show any evidence of pinaverium bromide interfering with the action or activity of any of the drugs studied.

[Chondromyxoid fibroma of the cervical spine. Apropos of a case treated by partial vertebrectomy]. / Fibrome chondro-myxoïde du rachis cervical. A propos d'un cas traité par vertébrectomie partielle.

A case of chondromyxoid fibroma revelated by cervicalgias and involving the right part of the 5th cervical vertebra is reported. This uncommon cartilaginous tumor is usually described in the metaphysis of long bones and appears very rare in the spine. If radiological aspects have been reported, the majors series do not describe a typical appearance of vertebral lesions; our patient is one of the first to have been evaluated by CT scan. Chondromyxoid fibromas are benign tumors, but recurrence is possible especially when treated by curettage alone. In our case, operated on two stages, the resection seemed sufficiently large and CT control on the 10th month did not show evidence of recurrence. Clinical and radiologic findings, and surgical management of these vertebral tumors are discussed.

[Hematological and clinical manifestations of bone marrow metastasis of carcinomas. Apropos of 36 cases verified by biopsy]. / Manifestations cliniques et hématologiques des métastases médullaires des carcinomes. A propos de 36 cas prouvés par biopsie.

A retrospective study of 36 cases of bone marrow metastases from carcinoma is reported. In all cases, the presence of tumour cells was confirmed by needle biopsy of the bone marrow. The clinical picture was fairly typical: decline in general health, fever, bony pain and skin and mucosal hemorrhages. Radiological lesions of the skeleton were present in 64% of cases. Sometimes the blood disorders were isolated. Anemia was almost constant (86), normochromic, normocytic, and may be associated with leukocytosis and thrombopenia. Pancytopenia is rarer as also is a rise in the number of platelets. Erythremia, very suggestive, is demonstrated in 73% of the blood smears. In 31% of the slides examined again, schizocytes were found among the normal red cells. Disorders of hemostasis were easily circumscribed. As fibrinolysis was sometime found, hemostasis was studied as a routine in all patients. The special recruitment of a hematology unit explains the high frequency of blood abnormalities in this series of bone metastases.

[Bone-marrow biopsy in chronic myeloid leukemia. Value of the initial examination]. / La biopsie médullaire dans la leucémie myéloïde chronique. I.- Intétêt lors de l'examen initial

In 31 patients with chronic myeloid leukemia, the initial bone marrow biopsy constantly showed considerable cell richness. The maturation of the granulocytes was harmonious in 52% of cases, with a predominance of myelocytes in 32% of cases, and groups of myeloblasts in 13% of cases. Eosinophilia was frequent and fairly intense. Fairly numerous loaded cells and Charcot-Leyden crystals were signs of granulocyte failure in the bone marrow. The erythroblasts were reduced, the megakaryocytes increased. Myelofibrosis was present in 45% of cases. This gave a very characteristic histological appearance. It was not possible to draw up correlations between the type of granulocyte maturation and/or the presence of myelofibrosis and, on the other hand, the clinical course of the disease, but the small number of case studied both in our series and in the literature do not permit one to carry out a proper statistical study.

[Bone-marrow biopsy in chronic myeloid leukemia. Significance during development]. / La biopsie médullaire dans la leucémie myéloïde chronique. II. - Intérêt au cours de l'évolution

In 29 patients bone marrow biopsy carried out during the course of chronic myeloid luekemia, permitted the authors to divide up the patients into 5 histologically different groups according to the association of 3 parameters: the richness in granulocytes, the state of the matrix, the degree of leukoblastosis. There was, in most cases, correspondence between the histological appearance and the clinical and laboratory symptoms. This was particularly clear when the patient entered the terminal phase of the disease. 4 of the 5 histological groups had an unfavourable short-term prognosis, i.e., granulocyte hyperplasia with myelofibrosis, aplasia with normal matrix or with myelofibrosis and massive leukoblast invasion.